<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:6acec017-6236-4f88-94ad-fc131296537c,g:4be40685-65eb-429b-9b75-83fbff98249d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://gxo.com/role/ConsolidatedStatementsofChangesinEquity" xlink:type="simple" xlink:href="gxo-20241231.xsd#ConsolidatedStatementsofChangesinEquity"/>
  <link:definitionLink xlink:role="http://gxo.com/role/ConsolidatedStatementsofChangesinEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_e111c566-6ea8-45c0-9dc9-b038e812e7db" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_fa6c3f02-8bf0-4b77-a556-8b40055baf46" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_e111c566-6ea8-45c0-9dc9-b038e812e7db" xlink:to="loc_us-gaap_StatementTable_fa6c3f02-8bf0-4b77-a556-8b40055baf46" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_cb918b6f-da8c-4481-acb0-d3f01573d120" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_fa6c3f02-8bf0-4b77-a556-8b40055baf46" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_cb918b6f-da8c-4481-acb0-d3f01573d120" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_cb918b6f-da8c-4481-acb0-d3f01573d120_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_cb918b6f-da8c-4481-acb0-d3f01573d120" xlink:to="loc_us-gaap_EquityComponentDomain_cb918b6f-da8c-4481-acb0-d3f01573d120_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_34652bb7-0a46-40a5-a8b1-9eca1e1d411a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_cb918b6f-da8c-4481-acb0-d3f01573d120" xlink:to="loc_us-gaap_EquityComponentDomain_34652bb7-0a46-40a5-a8b1-9eca1e1d411a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ParentMember_d46da2f4-4feb-4a5d-94a3-382a3f67e5e2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_34652bb7-0a46-40a5-a8b1-9eca1e1d411a" xlink:to="loc_us-gaap_ParentMember_d46da2f4-4feb-4a5d-94a3-382a3f67e5e2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_1af3a505-1df3-4f53-9833-f645a370bba9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_d46da2f4-4feb-4a5d-94a3-382a3f67e5e2" xlink:to="loc_us-gaap_CommonStockMember_1af3a505-1df3-4f53-9833-f645a370bba9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_085e9955-115c-4709-9d62-648400641e49" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_d46da2f4-4feb-4a5d-94a3-382a3f67e5e2" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_085e9955-115c-4709-9d62-648400641e49" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_b3af15c6-3854-46b3-a5d3-3829e433eea8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_d46da2f4-4feb-4a5d-94a3-382a3f67e5e2" xlink:to="loc_us-gaap_RetainedEarningsMember_b3af15c6-3854-46b3-a5d3-3829e433eea8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_080f1904-fc7f-47e3-ac1e-a6118afc57a5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ParentMember_d46da2f4-4feb-4a5d-94a3-382a3f67e5e2" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_080f1904-fc7f-47e3-ac1e-a6118afc57a5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_8a5b60fa-36d3-4ef8-987f-7f2cd99a2c1b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_34652bb7-0a46-40a5-a8b1-9eca1e1d411a" xlink:to="loc_us-gaap_NoncontrollingInterestMember_8a5b60fa-36d3-4ef8-987f-7f2cd99a2c1b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_e111c566-6ea8-45c0-9dc9-b038e812e7db" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_7bb34fe2-7cde-4db4-9767-f3dc07700e06" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_7bb34fe2-7cde-4db4-9767-f3dc07700e06" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_7d453faa-0c18-445c-a749-72d769e9fcf3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_7d453faa-0c18-445c-a749-72d769e9fcf3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_fc9d59f1-6b8b-45a2-97af-6d8b4a36e14b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_ProfitLoss_fc9d59f1-6b8b-45a2-97af-6d8b4a36e14b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_3caac4e7-1b94-412f-95b5-f313c0d741af" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_3caac4e7-1b94-412f-95b5-f313c0d741af" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_cda27eff-2c5e-4675-9e8c-48d2da5a1c28" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_cda27eff-2c5e-4675-9e8c-48d2da5a1c28" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_9c4f2d66-d96d-40a8-afd3-da16a78fe3c3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_9c4f2d66-d96d-40a8-afd3-da16a78fe3c3" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_c945b6ff-6efe-46c9-8f1c-f1b2c815e857" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_c945b6ff-6efe-46c9-8f1c-f1b2c815e857" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_92b4aa66-09b0-4ff3-aee2-ad24dddba617" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_92b4aa66-09b0-4ff3-aee2-ad24dddba617" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_367e46d8-a9c2-4143-ad3d-5b6cbc8e8883" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_367e46d8-a9c2-4143-ad3d-5b6cbc8e8883" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_2acbdf58-7add-412f-9e0a-32f550e98893" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_2acbdf58-7add-412f-9e0a-32f550e98893" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_7b92f520-c1d7-4ade-a194-894a6cf1e21e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_7b92f520-c1d7-4ade-a194-894a6cf1e21e" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityOther_ed3df735-832c-4628-9b5e-d1ec8f6f110f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_62ae939e-4ced-4f4f-94b2-9c7a1de9c2f3" xlink:to="loc_us-gaap_StockholdersEquityOther_ed3df735-832c-4628-9b5e-d1ec8f6f110f" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_aa252e26-ccd0-4240-9326-365c6bbd8b0e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_30f82520-66d7-4712-839f-a0e02d2337ce" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/BasisofPresentationandSignificantAccountingPoliciesUsefulLivesDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#BasisofPresentationandSignificantAccountingPoliciesUsefulLivesDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/BasisofPresentationandSignificantAccountingPoliciesUsefulLivesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_00c7b719-9de3-42be-bfe7-77d3ee5ff711" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2a5bedb8-0611-4436-a476-7914f3f64113" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_00c7b719-9de3-42be-bfe7-77d3ee5ff711" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2a5bedb8-0611-4436-a476-7914f3f64113" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f1e90588-6196-4f41-80df-90cd3d17377a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2a5bedb8-0611-4436-a476-7914f3f64113" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f1e90588-6196-4f41-80df-90cd3d17377a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_f1e90588-6196-4f41-80df-90cd3d17377a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f1e90588-6196-4f41-80df-90cd3d17377a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_f1e90588-6196-4f41-80df-90cd3d17377a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_961ac887-4e22-493d-80d9-e008000ec7a3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f1e90588-6196-4f41-80df-90cd3d17377a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_961ac887-4e22-493d-80d9-e008000ec7a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingMember_d62f46b2-ae40-494d-8023-7a14bc862d95" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BuildingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_961ac887-4e22-493d-80d9-e008000ec7a3" xlink:to="loc_us-gaap_BuildingMember_d62f46b2-ae40-494d-8023-7a14bc862d95" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherMachineryAndEquipmentMember_fe3335f9-e9e0-4aef-be5c-e68feb60cf40" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherMachineryAndEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_961ac887-4e22-493d-80d9-e008000ec7a3" xlink:to="loc_us-gaap_OtherMachineryAndEquipmentMember_fe3335f9-e9e0-4aef-be5c-e68feb60cf40" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TechnologyEquipmentMember_640b6e07-62c7-40ad-aac2-4990be000f93" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TechnologyEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_961ac887-4e22-493d-80d9-e008000ec7a3" xlink:to="loc_us-gaap_TechnologyEquipmentMember_640b6e07-62c7-40ad-aac2-4990be000f93" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_ddb97030-f733-4396-b4a8-23e2592925b2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_961ac887-4e22-493d-80d9-e008000ec7a3" xlink:to="loc_us-gaap_ComputerEquipmentMember_ddb97030-f733-4396-b4a8-23e2592925b2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SoftwareDevelopmentMember_00970022-e254-46e7-a14c-252e6e94cf42" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SoftwareDevelopmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_961ac887-4e22-493d-80d9-e008000ec7a3" xlink:to="loc_us-gaap_SoftwareDevelopmentMember_00970022-e254-46e7-a14c-252e6e94cf42" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_c5ea9da8-1576-4339-b512-c8b2943d831c" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_2a5bedb8-0611-4436-a476-7914f3f64113" xlink:to="loc_srt_RangeAxis_c5ea9da8-1576-4339-b512-c8b2943d831c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c5ea9da8-1576-4339-b512-c8b2943d831c_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_c5ea9da8-1576-4339-b512-c8b2943d831c" xlink:to="loc_srt_RangeMember_c5ea9da8-1576-4339-b512-c8b2943d831c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c7574f97-46a5-477e-b9b9-ff6244c675ef" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_c5ea9da8-1576-4339-b512-c8b2943d831c" xlink:to="loc_srt_RangeMember_c7574f97-46a5-477e-b9b9-ff6244c675ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_8c29a658-a809-4bb7-a4f1-0efcb603a823" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c7574f97-46a5-477e-b9b9-ff6244c675ef" xlink:to="loc_srt_MinimumMember_8c29a658-a809-4bb7-a4f1-0efcb603a823" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_9a414341-e8a1-4fab-9a5c-bb420a44e142" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c7574f97-46a5-477e-b9b9-ff6244c675ef" xlink:to="loc_srt_MaximumMember_9a414341-e8a1-4fab-9a5c-bb420a44e142" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_09b04757-b872-41d4-b25b-bf7879189492" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_00c7b719-9de3-42be-bfe7-77d3ee5ff711" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_09b04757-b872-41d4-b25b-bf7879189492" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/RevenueRecognitionRevenueDisaggregatedbyGeographicAreaDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#RevenueRecognitionRevenueDisaggregatedbyGeographicAreaDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/RevenueRecognitionRevenueDisaggregatedbyGeographicAreaDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_1c7c56c6-75fc-4fbd-81bc-2234054ac735" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_3276c32a-21c3-4092-a853-12e9a59fddb1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_1c7c56c6-75fc-4fbd-81bc-2234054ac735" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_3276c32a-21c3-4092-a853-12e9a59fddb1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_d7183cff-fb95-4f04-b841-2538baf079ca" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_3276c32a-21c3-4092-a853-12e9a59fddb1" xlink:to="loc_srt_StatementGeographicalAxis_d7183cff-fb95-4f04-b841-2538baf079ca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_d7183cff-fb95-4f04-b841-2538baf079ca_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_d7183cff-fb95-4f04-b841-2538baf079ca" xlink:to="loc_srt_SegmentGeographicalDomain_d7183cff-fb95-4f04-b841-2538baf079ca_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_2a4232a8-0837-463b-a0f1-dba1bbde368d" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_d7183cff-fb95-4f04-b841-2538baf079ca" xlink:to="loc_srt_SegmentGeographicalDomain_2a4232a8-0837-463b-a0f1-dba1bbde368d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_GB_89993534-c005-4532-9453-a7e5965eb633" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_GB"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2a4232a8-0837-463b-a0f1-dba1bbde368d" xlink:to="loc_country_GB_89993534-c005-4532-9453-a7e5965eb633" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_c8a0bf67-cec2-42bb-a848-698be4ef92cb" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2a4232a8-0837-463b-a0f1-dba1bbde368d" xlink:to="loc_country_US_c8a0bf67-cec2-42bb-a848-698be4ef92cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_NL_c1259d93-c241-4764-a649-a33f593697ee" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_NL"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2a4232a8-0837-463b-a0f1-dba1bbde368d" xlink:to="loc_country_NL_c1259d93-c241-4764-a649-a33f593697ee" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_FR_d0cb313b-1e54-40e1-a24c-06a2d51affb5" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_FR"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2a4232a8-0837-463b-a0f1-dba1bbde368d" xlink:to="loc_country_FR_d0cb313b-1e54-40e1-a24c-06a2d51affb5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_ES_cb41be43-8a26-47ea-acb5-5f6df960171f" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_ES"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2a4232a8-0837-463b-a0f1-dba1bbde368d" xlink:to="loc_country_ES_cb41be43-8a26-47ea-acb5-5f6df960171f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_IT_de07bf13-de11-4834-9251-71165e0e8112" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_IT"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2a4232a8-0837-463b-a0f1-dba1bbde368d" xlink:to="loc_country_IT_de07bf13-de11-4834-9251-71165e0e8112" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_OtherGeographicalAreasMember_40732d33-edba-489b-a614-057ae7029591" xlink:href="gxo-20241231.xsd#gxo_OtherGeographicalAreasMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2a4232a8-0837-463b-a0f1-dba1bbde368d" xlink:to="loc_gxo_OtherGeographicalAreasMember_40732d33-edba-489b-a614-057ae7029591" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_2f03fe25-72b1-4ad3-b4a6-68c158341871" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_1c7c56c6-75fc-4fbd-81bc-2234054ac735" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_2f03fe25-72b1-4ad3-b4a6-68c158341871" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/RevenueRecognitionRevenueDisaggregatedbyIndustrySectorDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#RevenueRecognitionRevenueDisaggregatedbyIndustrySectorDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/RevenueRecognitionRevenueDisaggregatedbyIndustrySectorDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_95d3afd2-766d-4ec4-87e9-27891ad6179f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_f53d054a-9400-4fe8-bc83-dadf3588254e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_95d3afd2-766d-4ec4-87e9-27891ad6179f" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_f53d054a-9400-4fe8-bc83-dadf3588254e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_1303a0b2-b655-43f0-9395-1d3c9356b400" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_f53d054a-9400-4fe8-bc83-dadf3588254e" xlink:to="loc_srt_ProductOrServiceAxis_1303a0b2-b655-43f0-9395-1d3c9356b400" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_1303a0b2-b655-43f0-9395-1d3c9356b400_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_1303a0b2-b655-43f0-9395-1d3c9356b400" xlink:to="loc_srt_ProductsAndServicesDomain_1303a0b2-b655-43f0-9395-1d3c9356b400_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_b6618756-a1bb-41f6-b448-f01806bc69ea" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_1303a0b2-b655-43f0-9395-1d3c9356b400" xlink:to="loc_srt_ProductsAndServicesDomain_b6618756-a1bb-41f6-b448-f01806bc69ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_OmnichannelRetailMember_4f28e0df-107d-4f9d-bfb4-d1bcd8f5b63c" xlink:href="gxo-20241231.xsd#gxo_OmnichannelRetailMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_b6618756-a1bb-41f6-b448-f01806bc69ea" xlink:to="loc_gxo_OmnichannelRetailMember_4f28e0df-107d-4f9d-bfb4-d1bcd8f5b63c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_TechnologyAndConsumerElectronicsMember_99f7f791-5423-4abe-bfc8-1a27097e1def" xlink:href="gxo-20241231.xsd#gxo_TechnologyAndConsumerElectronicsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_b6618756-a1bb-41f6-b448-f01806bc69ea" xlink:to="loc_gxo_TechnologyAndConsumerElectronicsMember_99f7f791-5423-4abe-bfc8-1a27097e1def" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_IndustrialAndManufacturingMember_46dd1e34-3ce4-484f-9504-a1d3e0b7fb7d" xlink:href="gxo-20241231.xsd#gxo_IndustrialAndManufacturingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_b6618756-a1bb-41f6-b448-f01806bc69ea" xlink:to="loc_gxo_IndustrialAndManufacturingMember_46dd1e34-3ce4-484f-9504-a1d3e0b7fb7d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FoodAndBeverageMember_a674288f-e5f9-4ff3-9b31-65d3599aec0d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FoodAndBeverageMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_b6618756-a1bb-41f6-b448-f01806bc69ea" xlink:to="loc_us-gaap_FoodAndBeverageMember_a674288f-e5f9-4ff3-9b31-65d3599aec0d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_ConsumerPackagedGoodsMember_66331297-7184-4881-94a4-a88ed24631f9" xlink:href="gxo-20241231.xsd#gxo_ConsumerPackagedGoodsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_b6618756-a1bb-41f6-b448-f01806bc69ea" xlink:to="loc_gxo_ConsumerPackagedGoodsMember_66331297-7184-4881-94a4-a88ed24631f9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductAndServiceOtherMember_addf6295-1caf-4c91-8267-abb534209884" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProductAndServiceOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_b6618756-a1bb-41f6-b448-f01806bc69ea" xlink:to="loc_us-gaap_ProductAndServiceOtherMember_addf6295-1caf-4c91-8267-abb534209884" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_07a22b15-f3f6-4ee3-b68e-79a4129c3f0b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_95d3afd2-766d-4ec4-87e9-27891ad6179f" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_07a22b15-f3f6-4ee3-b68e-79a4129c3f0b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/AcquisitionsNarrativeDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#AcquisitionsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/AcquisitionsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_b32d486d-3f60-4f69-9865-e424a52bd123" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_b32d486d-3f60-4f69-9865-e424a52bd123" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_9993f3e0-546b-4400-8dcd-80ea6e2d7028" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_b32d486d-3f60-4f69-9865-e424a52bd123" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_9993f3e0-546b-4400-8dcd-80ea6e2d7028" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_9993f3e0-546b-4400-8dcd-80ea6e2d7028_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_9993f3e0-546b-4400-8dcd-80ea6e2d7028" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_9993f3e0-546b-4400-8dcd-80ea6e2d7028_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_634f472b-9563-48df-aeaa-83029719a17f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_9993f3e0-546b-4400-8dcd-80ea6e2d7028" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_634f472b-9563-48df-aeaa-83029719a17f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_WincantonMember_a85b5f2e-d2c6-4e83-a6b5-1a3b97b56039" xlink:href="gxo-20241231.xsd#gxo_WincantonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_634f472b-9563-48df-aeaa-83029719a17f" xlink:to="loc_gxo_WincantonMember_a85b5f2e-d2c6-4e83-a6b5-1a3b97b56039" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_PFSwebIncMember_6987656e-3e57-43b3-9969-dc8c4fd425cd" xlink:href="gxo-20241231.xsd#gxo_PFSwebIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_634f472b-9563-48df-aeaa-83029719a17f" xlink:to="loc_gxo_PFSwebIncMember_6987656e-3e57-43b3-9969-dc8c4fd425cd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_77d177ea-7776-4d3c-9eb0-2ed46deeb74c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_b32d486d-3f60-4f69-9865-e424a52bd123" xlink:to="loc_us-gaap_CreditFacilityAxis_77d177ea-7776-4d3c-9eb0-2ed46deeb74c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_77d177ea-7776-4d3c-9eb0-2ed46deeb74c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_77d177ea-7776-4d3c-9eb0-2ed46deeb74c" xlink:to="loc_us-gaap_CreditFacilityDomain_77d177ea-7776-4d3c-9eb0-2ed46deeb74c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_dd0e127a-ff1a-4fda-a894-0204ef8b8923" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_77d177ea-7776-4d3c-9eb0-2ed46deeb74c" xlink:to="loc_us-gaap_CreditFacilityDomain_dd0e127a-ff1a-4fda-a894-0204ef8b8923" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnsecuredDebtMember_52fba370-e17f-45f0-862e-b849474e35cd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_UnsecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_dd0e127a-ff1a-4fda-a894-0204ef8b8923" xlink:to="loc_us-gaap_UnsecuredDebtMember_52fba370-e17f-45f0-862e-b849474e35cd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_3f910dc0-7326-46c4-8ecc-4a5ca5b40d68" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_b32d486d-3f60-4f69-9865-e424a52bd123" xlink:to="loc_us-gaap_DebtInstrumentAxis_3f910dc0-7326-46c4-8ecc-4a5ca5b40d68" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_3f910dc0-7326-46c4-8ecc-4a5ca5b40d68_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_3f910dc0-7326-46c4-8ecc-4a5ca5b40d68" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_3f910dc0-7326-46c4-8ecc-4a5ca5b40d68_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_9e84e5d3-00ad-416a-aa43-8c0fca4ad8b2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_3f910dc0-7326-46c4-8ecc-4a5ca5b40d68" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_9e84e5d3-00ad-416a-aa43-8c0fca4ad8b2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_ThreeYearTermLoanDue2027Member_497f2142-4aa0-4b9f-91e2-dca3f0fc5452" xlink:href="gxo-20241231.xsd#gxo_ThreeYearTermLoanDue2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_9e84e5d3-00ad-416a-aa43-8c0fca4ad8b2" xlink:to="loc_gxo_ThreeYearTermLoanDue2027Member_497f2142-4aa0-4b9f-91e2-dca3f0fc5452" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2029And2034Member_a3221eb0-0dbd-48d9-bb8c-8c21b638d9bc" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2029And2034Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_9e84e5d3-00ad-416a-aa43-8c0fca4ad8b2" xlink:to="loc_gxo_UnsecuredNotesDue2029And2034Member_a3221eb0-0dbd-48d9-bb8c-8c21b638d9bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_d2c0fefb-dc87-4152-b4b9-17001f7c8810" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_b32d486d-3f60-4f69-9865-e424a52bd123" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_d2c0fefb-dc87-4152-b4b9-17001f7c8810" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_d2c0fefb-dc87-4152-b4b9-17001f7c8810_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_d2c0fefb-dc87-4152-b4b9-17001f7c8810" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_d2c0fefb-dc87-4152-b4b9-17001f7c8810_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_370023e5-52c5-4b78-a3f9-fa9f3e6c2150" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_d2c0fefb-dc87-4152-b4b9-17001f7c8810" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_370023e5-52c5-4b78-a3f9-fa9f3e6c2150" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_be687bdf-4f78-4bef-868c-cbe5b1553570" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_370023e5-52c5-4b78-a3f9-fa9f3e6c2150" xlink:to="loc_us-gaap_LineOfCreditMember_be687bdf-4f78-4bef-868c-cbe5b1553570" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionSharePrice_4e722b72-436c-42e1-a267-a830a983071c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionSharePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:to="loc_us-gaap_BusinessAcquisitionSharePrice_4e722b72-436c-42e1-a267-a830a983071c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_9a80f667-bfd7-4a06-b5fb-2646c666cc31" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_9a80f667-bfd7-4a06-b5fb-2646c666cc31" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_a90b4764-dd5d-46dd-86cd-ff5ea380dfab" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_a90b4764-dd5d-46dd-86cd-ff5ea380dfab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_29b667dd-d92f-4e2b-9892-016b64ab8cbd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:to="loc_us-gaap_DebtInstrumentTerm_29b667dd-d92f-4e2b-9892-016b64ab8cbd" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_32d6e099-77e9-46ef-bd02-f4d8be43086f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_32d6e099-77e9-46ef-bd02-f4d8be43086f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_51b81076-7146-4fbf-b619-bb4eea4c6362" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:to="loc_us-gaap_BusinessCombinationProFormaInformationRevenueOfAcquireeSinceAcquisitionDateActual_51b81076-7146-4fbf-b619-bb4eea4c6362" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationProFormaInformationEarningsOrLossOfAcquireeSinceAcquisitionDateActual_15bf2a56-f0bf-4a95-98b5-2a0d098500d3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationProFormaInformationEarningsOrLossOfAcquireeSinceAcquisitionDateActual"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:to="loc_us-gaap_BusinessCombinationProFormaInformationEarningsOrLossOfAcquireeSinceAcquisitionDateActual_15bf2a56-f0bf-4a95-98b5-2a0d098500d3" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_BusinessCombinationRecognizedIdentifiableAssetAcquiredAndLiabilityAssumedOperatingAndFinanceLeaseLiability_2bdd25e7-ef42-46d4-9bf2-38c94f98f369" xlink:href="gxo-20241231.xsd#gxo_BusinessCombinationRecognizedIdentifiableAssetAcquiredAndLiabilityAssumedOperatingAndFinanceLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:to="loc_gxo_BusinessCombinationRecognizedIdentifiableAssetAcquiredAndLiabilityAssumedOperatingAndFinanceLeaseLiability_2bdd25e7-ef42-46d4-9bf2-38c94f98f369" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_d8f78200-5eb9-497d-929d-6544db70e669" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_d8f78200-5eb9-497d-929d-6544db70e669" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_6edb1f44-2e00-472b-9c50-078abbbb919d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_38180fe1-39d7-4471-ac61-f48d279e6165" xlink:to="loc_us-gaap_Goodwill_6edb1f44-2e00-472b-9c50-078abbbb919d" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/AcquisitionScheduleofFairValueofAssetsAcquiredandLiabilitiesAssumedatAcquisitionDateDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#AcquisitionScheduleofFairValueofAssetsAcquiredandLiabilitiesAssumedatAcquisitionDateDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/AcquisitionScheduleofFairValueofAssetsAcquiredandLiabilitiesAssumedatAcquisitionDateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_20f62b8e-f9fb-4137-b32c-2a32cbc319a9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3c5cdadc-69eb-4ced-ac7b-84c210af09b0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_20f62b8e-f9fb-4137-b32c-2a32cbc319a9" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3c5cdadc-69eb-4ced-ac7b-84c210af09b0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_6ddbd59a-5343-4b86-87c3-40a6c969f584" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3c5cdadc-69eb-4ced-ac7b-84c210af09b0" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_6ddbd59a-5343-4b86-87c3-40a6c969f584" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6ddbd59a-5343-4b86-87c3-40a6c969f584_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_6ddbd59a-5343-4b86-87c3-40a6c969f584" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6ddbd59a-5343-4b86-87c3-40a6c969f584_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6c261b15-b837-4676-9446-70ba0a4d5db4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_6ddbd59a-5343-4b86-87c3-40a6c969f584" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6c261b15-b837-4676-9446-70ba0a4d5db4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_WincantonMember_d65848a1-34d3-4d07-aba9-a09878e4bbd1" xlink:href="gxo-20241231.xsd#gxo_WincantonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6c261b15-b837-4676-9446-70ba0a4d5db4" xlink:to="loc_gxo_WincantonMember_d65848a1-34d3-4d07-aba9-a09878e4bbd1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_c6f4d0b7-566c-4016-8fa3-c29cc106cdf2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_20f62b8e-f9fb-4137-b32c-2a32cbc319a9" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_c6f4d0b7-566c-4016-8fa3-c29cc106cdf2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_481ba240-4df3-432d-ac18-ee89bb5b013a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_c6f4d0b7-566c-4016-8fa3-c29cc106cdf2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_481ba240-4df3-432d-ac18-ee89bb5b013a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_763b8839-3708-493f-9711-6cc8f7a23662" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_481ba240-4df3-432d-ac18-ee89bb5b013a" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_763b8839-3708-493f-9711-6cc8f7a23662" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_f1945ac9-3a98-474c-83c5-1faf09265dce" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_481ba240-4df3-432d-ac18-ee89bb5b013a" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_f1945ac9-3a98-474c-83c5-1faf09265dce" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_723bdd09-7243-4c9f-87d0-cf88c740e152" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_481ba240-4df3-432d-ac18-ee89bb5b013a" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_723bdd09-7243-4c9f-87d0-cf88c740e152" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_3acc7515-a835-433c-93ed-985c12d4262b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsAbstract_481ba240-4df3-432d-ac18-ee89bb5b013a" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssets_3acc7515-a835-433c-93ed-985c12d4262b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_fbaf3da1-4204-47de-8ba1-3b2bc93954e8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_c6f4d0b7-566c-4016-8fa3-c29cc106cdf2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_fbaf3da1-4204-47de-8ba1-3b2bc93954e8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_42e98671-e616-4bf2-b803-e14ebe1cb16e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_fbaf3da1-4204-47de-8ba1-3b2bc93954e8" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_42e98671-e616-4bf2-b803-e14ebe1cb16e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseAssets_e077fa1a-776c-4d5d-8a88-2d63a2f5628f" xlink:href="gxo-20241231.xsd#gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_fbaf3da1-4204-47de-8ba1-3b2bc93954e8" xlink:to="loc_gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseAssets_e077fa1a-776c-4d5d-8a88-2d63a2f5628f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_854c5308-0064-4d29-a015-cd0bcca2162a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_fbaf3da1-4204-47de-8ba1-3b2bc93954e8" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_854c5308-0064-4d29-a015-cd0bcca2162a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_b063b809-62c0-462b-a57c-8dc2f543e540" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_fbaf3da1-4204-47de-8ba1-3b2bc93954e8" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_b063b809-62c0-462b-a57c-8dc2f543e540" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssets_a0d6e12b-b498-4ad3-9367-8137727b8249" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssetsAbstract_fbaf3da1-4204-47de-8ba1-3b2bc93954e8" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentAssets_a0d6e12b-b498-4ad3-9367-8137727b8249" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_bbfb7891-97a9-48d5-8203-82b393a8bd9b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssetsAbstract_c6f4d0b7-566c-4016-8fa3-c29cc106cdf2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_bbfb7891-97a9-48d5-8203-82b393a8bd9b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_6d40ca9d-b10c-43aa-9696-b7d44e7a2f36" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_20f62b8e-f9fb-4137-b32c-2a32cbc319a9" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_6d40ca9d-b10c-43aa-9696-b7d44e7a2f36" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_a1dc9f16-320d-4c0f-b2bf-fd3c00c1fc9a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_6d40ca9d-b10c-43aa-9696-b7d44e7a2f36" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_a1dc9f16-320d-4c0f-b2bf-fd3c00c1fc9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_68dca856-9c56-48ee-ad11-77eee8699d4c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_a1dc9f16-320d-4c0f-b2bf-fd3c00c1fc9a" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_68dca856-9c56-48ee-ad11-77eee8699d4c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_7ab58336-87c8-4c2b-be54-7f45c8cc7e4a" xlink:href="gxo-20241231.xsd#gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_a1dc9f16-320d-4c0f-b2bf-fd3c00c1fc9a" xlink:to="loc_gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccruedExpenses_7ab58336-87c8-4c2b-be54-7f45c8cc7e4a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesLongTermDebt_f45643df-b5a1-4c88-b345-6614c048c7d0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_a1dc9f16-320d-4c0f-b2bf-fd3c00c1fc9a" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesLongTermDebt_f45643df-b5a1-4c88-b345-6614c048c7d0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOperatingLeaseLiabilities_8163d7c7-3a34-4a4d-8170-c9f9e8c921b2" xlink:href="gxo-20241231.xsd#gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOperatingLeaseLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_a1dc9f16-320d-4c0f-b2bf-fd3c00c1fc9a" xlink:to="loc_gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOperatingLeaseLiabilities_8163d7c7-3a34-4a4d-8170-c9f9e8c921b2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther_f8e2dbf0-2db4-4c3e-9929-dae5658569d1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_a1dc9f16-320d-4c0f-b2bf-fd3c00c1fc9a" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther_f8e2dbf0-2db4-4c3e-9929-dae5658569d1" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_de4320e3-649f-43aa-8c66-d44f3e27e71e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAbstract_a1dc9f16-320d-4c0f-b2bf-fd3c00c1fc9a" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_de4320e3-649f-43aa-8c66-d44f3e27e71e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesAbstract_9976e8eb-5497-498c-99c1-4bcfd4c18714" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_6d40ca9d-b10c-43aa-9696-b7d44e7a2f36" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesAbstract_9976e8eb-5497-498c-99c1-4bcfd4c18714" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_5bfc3da9-0a3a-444e-9dc4-fe8672dddb70" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesAbstract_9976e8eb-5497-498c-99c1-4bcfd4c18714" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt_5bfc3da9-0a3a-444e-9dc4-fe8672dddb70" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOperatingLeaseLiabilities_d193598b-bef3-485c-9f6b-a2f7d719c6cf" xlink:href="gxo-20241231.xsd#gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOperatingLeaseLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesAbstract_9976e8eb-5497-498c-99c1-4bcfd4c18714" xlink:to="loc_gxo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOperatingLeaseLiabilities_d193598b-bef3-485c-9f6b-a2f7d719c6cf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_a5f56f93-679a-4a10-9c2f-722f0d4ae82d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesAbstract_9976e8eb-5497-498c-99c1-4bcfd4c18714" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesOther_a5f56f93-679a-4a10-9c2f-722f0d4ae82d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilities_dd49d662-7500-4849-b1f7-aa8083861392" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesAbstract_9976e8eb-5497-498c-99c1-4bcfd4c18714" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilities_dd49d662-7500-4849-b1f7-aa8083861392" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_82bdb53a-aae0-43f3-a880-511b06eb8d5f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_6d40ca9d-b10c-43aa-9696-b7d44e7a2f36" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_82bdb53a-aae0-43f3-a880-511b06eb8d5f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_5577c430-8635-4fbd-9b41-5d4d3c736ec6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilitiesAbstract_6d40ca9d-b10c-43aa-9696-b7d44e7a2f36" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_5577c430-8635-4fbd-9b41-5d4d3c736ec6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_421580c4-ee81-44d0-8334-b82d1114e0f7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_20f62b8e-f9fb-4137-b32c-2a32cbc319a9" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_421580c4-ee81-44d0-8334-b82d1114e0f7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_2eed0a5c-0cb4-46fa-b4cf-e271a8db8e2c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_20f62b8e-f9fb-4137-b32c-2a32cbc319a9" xlink:to="loc_us-gaap_Goodwill_2eed0a5c-0cb4-46fa-b4cf-e271a8db8e2c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_e4ff919b-9d7e-488f-b4a5-8762d400e530" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_20f62b8e-f9fb-4137-b32c-2a32cbc319a9" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_e4ff919b-9d7e-488f-b4a5-8762d400e530" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossRealizedAfterTax_aa724cdf-00b8-414f-a29c-4bfe2fb195bb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignCurrencyTransactionGainLossRealizedAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_20f62b8e-f9fb-4137-b32c-2a32cbc319a9" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossRealizedAfterTax_aa724cdf-00b8-414f-a29c-4bfe2fb195bb" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/AcquisitionScheduleofProFormaInformationDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#AcquisitionScheduleofProFormaInformationDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/AcquisitionScheduleofProFormaInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_e800c7ae-410e-4807-a5f8-6ef344939c9d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_693fc144-9cb0-48a5-8ed3-3b5923d302af" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e800c7ae-410e-4807-a5f8-6ef344939c9d" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_693fc144-9cb0-48a5-8ed3-3b5923d302af" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_85eb4c6d-5628-462e-afc6-ed3a0ac63188" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_693fc144-9cb0-48a5-8ed3-3b5923d302af" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_85eb4c6d-5628-462e-afc6-ed3a0ac63188" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_85eb4c6d-5628-462e-afc6-ed3a0ac63188_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_85eb4c6d-5628-462e-afc6-ed3a0ac63188" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_85eb4c6d-5628-462e-afc6-ed3a0ac63188_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ab6c98ff-c8e3-4c54-86c2-6f3a4886929a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_85eb4c6d-5628-462e-afc6-ed3a0ac63188" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ab6c98ff-c8e3-4c54-86c2-6f3a4886929a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_WincantonMember_d7a92c66-f768-4200-be3f-c3e96194abd7" xlink:href="gxo-20241231.xsd#gxo_WincantonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ab6c98ff-c8e3-4c54-86c2-6f3a4886929a" xlink:to="loc_gxo_WincantonMember_d7a92c66-f768-4200-be3f-c3e96194abd7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_9256f80d-0855-4197-b368-368635e2ca12" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionsProFormaRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e800c7ae-410e-4807-a5f8-6ef344939c9d" xlink:to="loc_us-gaap_BusinessAcquisitionsProFormaRevenue_9256f80d-0855-4197-b368-368635e2ca12" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_BusinessAcquisitionProFormaNetIncomeLossFromContinuingOperationsBeforeIncomeTaxesNoncontrollingInterest_419767f8-c185-4aee-bbd5-db1fbfdfff8d" xlink:href="gxo-20241231.xsd#gxo_BusinessAcquisitionProFormaNetIncomeLossFromContinuingOperationsBeforeIncomeTaxesNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e800c7ae-410e-4807-a5f8-6ef344939c9d" xlink:to="loc_gxo_BusinessAcquisitionProFormaNetIncomeLossFromContinuingOperationsBeforeIncomeTaxesNoncontrollingInterest_419767f8-c185-4aee-bbd5-db1fbfdfff8d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_ea71b497-69b7-4395-a24d-a2b6298b5739" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_e800c7ae-410e-4807-a5f8-6ef344939c9d" xlink:to="loc_us-gaap_AssetImpairmentCharges_ea71b497-69b7-4395-a24d-a2b6298b5739" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/SegmentReportingScheduleofOperatingSegmentInformationDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#SegmentReportingScheduleofOperatingSegmentInformationDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/SegmentReportingScheduleofOperatingSegmentInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_7bcfb3fd-4d4c-430d-aa05-17f38d6cbb4e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_7bcfb3fd-4d4c-430d-aa05-17f38d6cbb4e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementBusinessSegmentsAxis_44416705-c600-46c6-9247-03f1baafedb7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementBusinessSegmentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_7bcfb3fd-4d4c-430d-aa05-17f38d6cbb4e" xlink:to="loc_us-gaap_StatementBusinessSegmentsAxis_44416705-c600-46c6-9247-03f1baafedb7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_44416705-c600-46c6-9247-03f1baafedb7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_44416705-c600-46c6-9247-03f1baafedb7" xlink:to="loc_us-gaap_SegmentDomain_44416705-c600-46c6-9247-03f1baafedb7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentDomain_76269ece-5dc4-40b9-970a-b9e01c515449" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SegmentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementBusinessSegmentsAxis_44416705-c600-46c6-9247-03f1baafedb7" xlink:to="loc_us-gaap_SegmentDomain_76269ece-5dc4-40b9-970a-b9e01c515449" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_ReportableSegmentMember_a2347efe-c5f5-4642-8126-b510596467bd" xlink:href="gxo-20241231.xsd#gxo_ReportableSegmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentDomain_76269ece-5dc4-40b9-970a-b9e01c515449" xlink:to="loc_gxo_ReportableSegmentMember_a2347efe-c5f5-4642-8126-b510596467bd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4c14a826-50c6-45c0-80f6-4daa79548968" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4c14a826-50c6-45c0-80f6-4daa79548968" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DirectOperatingCosts_eb01c4f2-481c-445c-b604-f1325d03f317" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DirectOperatingCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_DirectOperatingCosts_eb01c4f2-481c-445c-b604-f1325d03f317" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_SellingGeneralAndAdministrativeExpenseAdjusted_117d1efd-a1d0-4119-9765-39e31b93370c" xlink:href="gxo-20241231.xsd#gxo_SellingGeneralAndAdministrativeExpenseAdjusted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_gxo_SellingGeneralAndAdministrativeExpenseAdjusted_117d1efd-a1d0-4119-9765-39e31b93370c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherItemAmount_c87f245b-980b-4def-8071-c7a9bc5f30e4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SegmentReportingOtherItemAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_SegmentReportingOtherItemAmount_c87f245b-980b-4def-8071-c7a9bc5f30e4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_AdjustedEarningsBeforeInterestTaxesDepreciationAndAmortization_94427c68-ed7e-41c8-bac6-b0b092007c2b" xlink:href="gxo-20241231.xsd#gxo_AdjustedEarningsBeforeInterestTaxesDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_gxo_AdjustedEarningsBeforeInterestTaxesDepreciationAndAmortization_94427c68-ed7e-41c8-bac6-b0b092007c2b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_CorporateExpenses_86e41621-e58f-43c7-acbb-afc24067f566" xlink:href="gxo-20241231.xsd#gxo_CorporateExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_gxo_CorporateExpenses_86e41621-e58f-43c7-acbb-afc24067f566" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_155fb0f3-0c68-49fb-81f6-f54c41f1d276" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Depreciation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_Depreciation_155fb0f3-0c68-49fb-81f6-f54c41f1d276" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentForAmortization_e67892fe-7da8-4a8c-8fa2-66b8e73a3d1a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AdjustmentForAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_AdjustmentForAmortization_e67892fe-7da8-4a8c-8fa2-66b8e73a3d1a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_SpinoffTransactionAndIntegrationCosts_b2f3cf1b-c904-489a-ac75-85e430ce2e91" xlink:href="gxo-20241231.xsd#gxo_SpinoffTransactionAndIntegrationCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_gxo_SpinoffTransactionAndIntegrationCosts_b2f3cf1b-c904-489a-ac75-85e430ce2e91" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_30d28418-8a0a-4497-8d12-ee3bd7068b66" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_RestructuringCharges_30d28418-8a0a-4497-8d12-ee3bd7068b66" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalFees_89198d22-16fe-4136-a7be-7a10988e0c89" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LegalFees"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_LegalFees_89198d22-16fe-4136-a7be-7a10988e0c89" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_25374dab-1570-47f1-8a47-6d76da728c9d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignCurrencyTransactionGainLossUnrealized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_25374dab-1570-47f1-8a47-6d76da728c9d" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_dda4657f-5cb5-4610-9880-df9cf65b5ebd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_InterestExpenseNonoperating_dda4657f-5cb5-4610-9880-df9cf65b5ebd" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fec40e24-5889-4d1b-a46d-ce38a19e6ed6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_fec40e24-5889-4d1b-a46d-ce38a19e6ed6" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_8416a517-bf8d-4974-9543-f46a4f434fdd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_8416a517-bf8d-4974-9543-f46a4f434fdd" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_9ceb524d-ebee-436d-886f-13b17bfa9b88" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_64937ff7-80e2-4244-8626-26dd8c70e2ac" xlink:to="loc_us-gaap_ProfitLoss_9ceb524d-ebee-436d-886f-13b17bfa9b88" xlink:type="arc" order="15"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/SegmentInformationScheduleofLonglivedAssetsDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#SegmentInformationScheduleofLonglivedAssetsDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/SegmentInformationScheduleofLonglivedAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_e968672b-b42e-47a1-8c1b-86e2d057904b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_49332d4c-3ae2-43ed-acfe-c81f1ae33c0f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_e968672b-b42e-47a1-8c1b-86e2d057904b" xlink:to="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_49332d4c-3ae2-43ed-acfe-c81f1ae33c0f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_f45bd311-6dee-44b9-84e0-c356a46ff6ce" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_49332d4c-3ae2-43ed-acfe-c81f1ae33c0f" xlink:to="loc_srt_StatementGeographicalAxis_f45bd311-6dee-44b9-84e0-c356a46ff6ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_f45bd311-6dee-44b9-84e0-c356a46ff6ce_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_f45bd311-6dee-44b9-84e0-c356a46ff6ce" xlink:to="loc_srt_SegmentGeographicalDomain_f45bd311-6dee-44b9-84e0-c356a46ff6ce_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_1908a30e-7ffb-4d48-bb39-45ffb620e1ee" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_f45bd311-6dee-44b9-84e0-c356a46ff6ce" xlink:to="loc_srt_SegmentGeographicalDomain_1908a30e-7ffb-4d48-bb39-45ffb620e1ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_27fb0fe4-6c9e-4185-875a-d62662f6ded4" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_1908a30e-7ffb-4d48-bb39-45ffb620e1ee" xlink:to="loc_country_US_27fb0fe4-6c9e-4185-875a-d62662f6ded4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_GB_f3df3b84-ce3b-4654-9759-90a0583c8f3b" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_GB"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_1908a30e-7ffb-4d48-bb39-45ffb620e1ee" xlink:to="loc_country_GB_f3df3b84-ce3b-4654-9759-90a0583c8f3b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EuropeMember_39d24710-e17c-4c9c-97ea-e232f4b8eade" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_EuropeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_1908a30e-7ffb-4d48-bb39-45ffb620e1ee" xlink:to="loc_srt_EuropeMember_39d24710-e17c-4c9c-97ea-e232f4b8eade" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_NonUSAndNonUnitedKingdomMember_241070a5-9433-4f1b-8a29-7868f382b55a" xlink:href="gxo-20241231.xsd#gxo_NonUSAndNonUnitedKingdomMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_1908a30e-7ffb-4d48-bb39-45ffb620e1ee" xlink:to="loc_gxo_NonUSAndNonUnitedKingdomMember_241070a5-9433-4f1b-8a29-7868f382b55a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncurrentAssets_53342eed-ddea-47f1-ab63-046ed680b9a7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_e968672b-b42e-47a1-8c1b-86e2d057904b" xlink:to="loc_us-gaap_NoncurrentAssets_53342eed-ddea-47f1-ab63-046ed680b9a7" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/GoodwillDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#GoodwillDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/GoodwillDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_2c082ca2-a33b-4b3b-aebd-b786d4d108ed" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_6b8cd20d-0021-452c-9d4d-c2b06be72e3b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfGoodwillTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_GoodwillLineItems_2c082ca2-a33b-4b3b-aebd-b786d4d108ed" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_6b8cd20d-0021-452c-9d4d-c2b06be72e3b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_1dd70052-da37-486e-af5e-5d3ccbc8a197" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_6b8cd20d-0021-452c-9d4d-c2b06be72e3b" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_1dd70052-da37-486e-af5e-5d3ccbc8a197" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1dd70052-da37-486e-af5e-5d3ccbc8a197_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_1dd70052-da37-486e-af5e-5d3ccbc8a197" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_1dd70052-da37-486e-af5e-5d3ccbc8a197_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_02f144fa-be41-4b0f-8595-7ef44ee075c8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_1dd70052-da37-486e-af5e-5d3ccbc8a197" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_02f144fa-be41-4b0f-8595-7ef44ee075c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_WincantonMember_d9ca314f-b1a3-442d-ba65-4541c28bc454" xlink:href="gxo-20241231.xsd#gxo_WincantonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_02f144fa-be41-4b0f-8595-7ef44ee075c8" xlink:to="loc_gxo_WincantonMember_d9ca314f-b1a3-442d-ba65-4541c28bc454" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_PFSwebIncMember_eb240ef3-0fe8-450d-860a-c50f76420963" xlink:href="gxo-20241231.xsd#gxo_PFSwebIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_02f144fa-be41-4b0f-8595-7ef44ee075c8" xlink:to="loc_gxo_PFSwebIncMember_eb240ef3-0fe8-450d-860a-c50f76420963" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_942c0fb3-3d68-4e43-b90d-2af8a02dd45e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_2c082ca2-a33b-4b3b-aebd-b786d4d108ed" xlink:to="loc_us-gaap_GoodwillRollForward_942c0fb3-3d68-4e43-b90d-2af8a02dd45e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_120df84f-b884-4fe8-87bf-6810fe010c7c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_942c0fb3-3d68-4e43-b90d-2af8a02dd45e" xlink:to="loc_us-gaap_Goodwill_120df84f-b884-4fe8-87bf-6810fe010c7c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAcquiredDuringPeriod_8085ce80-d7fb-4868-a334-27fdfb9eb49f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillAcquiredDuringPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_942c0fb3-3d68-4e43-b90d-2af8a02dd45e" xlink:to="loc_us-gaap_GoodwillAcquiredDuringPeriod_8085ce80-d7fb-4868-a334-27fdfb9eb49f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_8d7104e9-81f9-4b85-9af7-f27f63b60603" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_942c0fb3-3d68-4e43-b90d-2af8a02dd45e" xlink:to="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_8d7104e9-81f9-4b85-9af7-f27f63b60603" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_30b4369a-3065-47c6-a4d6-b0200a039391" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_Goodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillPurchaseAccountingAdjustments_d0652474-bd76-497d-91c1-28cd2b9c87d4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillPurchaseAccountingAdjustments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_2c082ca2-a33b-4b3b-aebd-b786d4d108ed" xlink:to="loc_us-gaap_GoodwillPurchaseAccountingAdjustments_d0652474-bd76-497d-91c1-28cd2b9c87d4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_5d6d2bca-b67d-4bac-bd25-cfbe3230236b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_GoodwillImpairedAccumulatedImpairmentLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_2c082ca2-a33b-4b3b-aebd-b786d4d108ed" xlink:to="loc_us-gaap_GoodwillImpairedAccumulatedImpairmentLoss_5d6d2bca-b67d-4bac-bd25-cfbe3230236b" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/IntangibleAssetsScheduleofFinitelivedIntangibleAssetsDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#IntangibleAssetsScheduleofFinitelivedIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/IntangibleAssetsScheduleofFinitelivedIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_ed985c35-9e81-4224-be1b-948290b6f03e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_d5692244-4fea-4311-bf0e-042d3c1fd41a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_ed985c35-9e81-4224-be1b-948290b6f03e" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_d5692244-4fea-4311-bf0e-042d3c1fd41a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_42ec0880-0439-4d4d-a9ab-55cdb19e7a87" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_d5692244-4fea-4311-bf0e-042d3c1fd41a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_42ec0880-0439-4d4d-a9ab-55cdb19e7a87" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_42ec0880-0439-4d4d-a9ab-55cdb19e7a87_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_42ec0880-0439-4d4d-a9ab-55cdb19e7a87" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_42ec0880-0439-4d4d-a9ab-55cdb19e7a87_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_95686176-253e-4c06-803d-a5c8b938490a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_42ec0880-0439-4d4d-a9ab-55cdb19e7a87" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_95686176-253e-4c06-803d-a5c8b938490a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRelationshipsMember_93af12de-e62f-4724-bfe9-3ebc4ce0c633" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CustomerRelationshipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_95686176-253e-4c06-803d-a5c8b938490a" xlink:to="loc_us-gaap_CustomerRelationshipsMember_93af12de-e62f-4724-bfe9-3ebc4ce0c633" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrademarksAndTradeNamesMember_7b77ff9c-7a79-430b-a936-588a145b619b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TrademarksAndTradeNamesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_95686176-253e-4c06-803d-a5c8b938490a" xlink:to="loc_us-gaap_TrademarksAndTradeNamesMember_7b77ff9c-7a79-430b-a936-588a145b619b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_82d6ca49-b804-4818-963c-ba47944785c3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_95686176-253e-4c06-803d-a5c8b938490a" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_82d6ca49-b804-4818-963c-ba47944785c3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_14e5524f-22e0-4bea-874a-b2d7f56e8b71" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_ed985c35-9e81-4224-be1b-948290b6f03e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_14e5524f-22e0-4bea-874a-b2d7f56e8b71" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_07cf1c01-4fd2-43e8-a6ec-68c71e164131" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_ed985c35-9e81-4224-be1b-948290b6f03e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_07cf1c01-4fd2-43e8-a6ec-68c71e164131" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_58dfc682-a984-4319-bd28-dd62f6b4b4f1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_ed985c35-9e81-4224-be1b-948290b6f03e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_58dfc682-a984-4319-bd28-dd62f6b4b4f1" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/PropertyandEquipmentScheduleofPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#PropertyandEquipmentScheduleofPropertyPlantandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/PropertyandEquipmentScheduleofPropertyPlantandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_43c32f30-15b5-4d0d-b9fc-074d5ed0de2d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_6b7b33a6-baa3-4d23-b26e-20b7165aa3ed" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_43c32f30-15b5-4d0d-b9fc-074d5ed0de2d" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_6b7b33a6-baa3-4d23-b26e-20b7165aa3ed" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f93e8af2-0dd2-4e2b-a72f-2b2311880926" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_6b7b33a6-baa3-4d23-b26e-20b7165aa3ed" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f93e8af2-0dd2-4e2b-a72f-2b2311880926" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_f93e8af2-0dd2-4e2b-a72f-2b2311880926_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f93e8af2-0dd2-4e2b-a72f-2b2311880926" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_f93e8af2-0dd2-4e2b-a72f-2b2311880926_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_feaa3f40-2bc4-4e8b-8fcd-2f6c9d7386f5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_f93e8af2-0dd2-4e2b-a72f-2b2311880926" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_feaa3f40-2bc4-4e8b-8fcd-2f6c9d7386f5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_LandBuildingsAndLeaseholdImprovementsMember_8ddfd171-b242-4eef-a813-49c4094b5668" xlink:href="gxo-20241231.xsd#gxo_LandBuildingsAndLeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_feaa3f40-2bc4-4e8b-8fcd-2f6c9d7386f5" xlink:to="loc_gxo_LandBuildingsAndLeaseholdImprovementsMember_8ddfd171-b242-4eef-a813-49c4094b5668" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_WarehouseEquipmentFleetAndOtherMember_20c5e2fb-68d0-41af-b970-3bb816a27ad2" xlink:href="gxo-20241231.xsd#gxo_WarehouseEquipmentFleetAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_feaa3f40-2bc4-4e8b-8fcd-2f6c9d7386f5" xlink:to="loc_gxo_WarehouseEquipmentFleetAndOtherMember_20c5e2fb-68d0-41af-b970-3bb816a27ad2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_TechnologyAndAutomatedSystemsMember_27f9cd15-faf5-4a2f-958e-52512592b660" xlink:href="gxo-20241231.xsd#gxo_TechnologyAndAutomatedSystemsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_feaa3f40-2bc4-4e8b-8fcd-2f6c9d7386f5" xlink:to="loc_gxo_TechnologyAndAutomatedSystemsMember_27f9cd15-faf5-4a2f-958e-52512592b660" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_f2292a2f-aed6-45b5-b4f2-14a8124e3ad9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_feaa3f40-2bc4-4e8b-8fcd-2f6c9d7386f5" xlink:to="loc_us-gaap_ComputerEquipmentMember_f2292a2f-aed6-45b5-b4f2-14a8124e3ad9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SoftwareDevelopmentMember_80482d15-be62-4642-a107-d9d419eedba8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SoftwareDevelopmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_feaa3f40-2bc4-4e8b-8fcd-2f6c9d7386f5" xlink:to="loc_us-gaap_SoftwareDevelopmentMember_80482d15-be62-4642-a107-d9d419eedba8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_64a44fa0-00c6-4e3a-87d9-d51b84ec3f16" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_43c32f30-15b5-4d0d-b9fc-074d5ed0de2d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_64a44fa0-00c6-4e3a-87d9-d51b84ec3f16" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_98490619-39a4-4250-bd61-cdf2d1ca64cb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_43c32f30-15b5-4d0d-b9fc-074d5ed0de2d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_98490619-39a4-4250-bd61-cdf2d1ca64cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_c478a387-1548-438d-83a2-216599c7f8d9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_43c32f30-15b5-4d0d-b9fc-074d5ed0de2d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_c478a387-1548-438d-83a2-216599c7f8d9" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/LeasesSupplementalCashFlowsDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#LeasesSupplementalCashFlowsDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/LeasesSupplementalCashFlowsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_bc3e65cf-5f94-480b-a873-be264e781a98" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_258982ad-a5e4-4e23-868b-d9b162b1d0d9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_bc3e65cf-5f94-480b-a873-be264e781a98" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_258982ad-a5e4-4e23-868b-d9b162b1d0d9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_4a5c5bc3-3a98-4084-bb7f-1e01ed192e57" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_258982ad-a5e4-4e23-868b-d9b162b1d0d9" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_4a5c5bc3-3a98-4084-bb7f-1e01ed192e57" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4a5c5bc3-3a98-4084-bb7f-1e01ed192e57_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_4a5c5bc3-3a98-4084-bb7f-1e01ed192e57" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_4a5c5bc3-3a98-4084-bb7f-1e01ed192e57_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2771ec72-0ff4-4948-a4eb-37c8fcbc1114" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_4a5c5bc3-3a98-4084-bb7f-1e01ed192e57" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2771ec72-0ff4-4948-a4eb-37c8fcbc1114" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_PFSwebIncMember_0088696f-66b4-4fa0-8365-35d6dddfdf04" xlink:href="gxo-20241231.xsd#gxo_PFSwebIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2771ec72-0ff4-4948-a4eb-37c8fcbc1114" xlink:to="loc_gxo_PFSwebIncMember_0088696f-66b4-4fa0-8365-35d6dddfdf04" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_ClipperLogisticsPlcMember_1905f33e-1a95-4463-a813-bec3aab343f8" xlink:href="gxo-20241231.xsd#gxo_ClipperLogisticsPlcMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2771ec72-0ff4-4948-a4eb-37c8fcbc1114" xlink:to="loc_gxo_ClipperLogisticsPlcMember_1905f33e-1a95-4463-a813-bec3aab343f8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_KuehneNagelMember_b551ee40-94d1-4cca-ad01-f5c9009b9024" xlink:href="gxo-20241231.xsd#gxo_KuehneNagelMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2771ec72-0ff4-4948-a4eb-37c8fcbc1114" xlink:to="loc_gxo_KuehneNagelMember_b551ee40-94d1-4cca-ad01-f5c9009b9024" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasePayments_510cd111-07b7-4d7a-88b7-15f9c8a063e9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLeasePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_bc3e65cf-5f94-480b-a873-be264e781a98" xlink:to="loc_us-gaap_OperatingLeasePayments_510cd111-07b7-4d7a-88b7-15f9c8a063e9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestPaymentOnLiability_48838b71-c11f-4d2e-9b22-43d5205d7052" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FinanceLeaseInterestPaymentOnLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_bc3e65cf-5f94-480b-a873-be264e781a98" xlink:to="loc_us-gaap_FinanceLeaseInterestPaymentOnLiability_48838b71-c11f-4d2e-9b22-43d5205d7052" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_d80e1c72-b09e-4f39-89f3-46fba4f069e7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_bc3e65cf-5f94-480b-a873-be264e781a98" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_d80e1c72-b09e-4f39-89f3-46fba4f069e7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_f2724592-2ac2-4c15-9b1b-9550281c6c6b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_bc3e65cf-5f94-480b-a873-be264e781a98" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_f2724592-2ac2-4c15-9b1b-9550281c6c6b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_cc76848b-3977-49ca-b850-78dd7cb30d91" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_bc3e65cf-5f94-480b-a873-be264e781a98" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForFinanceLeaseLiability_cc76848b-3977-49ca-b850-78dd7cb30d91" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/LeasesNarrativeDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#LeasesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/LeasesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_e6aa1fac-9ce0-4ed1-b276-5b714318b455" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_3cb28c23-0714-4b83-bfb5-d46226c6b729" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_e6aa1fac-9ce0-4ed1-b276-5b714318b455" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_3cb28c23-0714-4b83-bfb5-d46226c6b729" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_6458de43-e875-4d8a-a768-b87588f1a788" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_3cb28c23-0714-4b83-bfb5-d46226c6b729" xlink:to="loc_srt_RangeAxis_6458de43-e875-4d8a-a768-b87588f1a788" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_6458de43-e875-4d8a-a768-b87588f1a788_default" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_6458de43-e875-4d8a-a768-b87588f1a788" xlink:to="loc_srt_RangeMember_6458de43-e875-4d8a-a768-b87588f1a788_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_20f37b3c-6e9d-4154-8aa0-da5754772f3c" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_6458de43-e875-4d8a-a768-b87588f1a788" xlink:to="loc_srt_RangeMember_20f37b3c-6e9d-4154-8aa0-da5754772f3c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_60432e7e-1335-46f8-b554-f43dfc2e9070" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_20f37b3c-6e9d-4154-8aa0-da5754772f3c" xlink:to="loc_srt_MinimumMember_60432e7e-1335-46f8-b554-f43dfc2e9070" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_bfcb8bbf-9f1e-4735-ba38-0d7723ef9966" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_20f37b3c-6e9d-4154-8aa0-da5754772f3c" xlink:to="loc_srt_MaximumMember_bfcb8bbf-9f1e-4735-ba38-0d7723ef9966" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationBalanceSheetAmount_a690e2c3-fdb4-4fbc-b3b4-64b9d10576bd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_UnrecordedUnconditionalPurchaseObligationBalanceSheetAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_e6aa1fac-9ce0-4ed1-b276-5b714318b455" xlink:to="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationBalanceSheetAmount_a690e2c3-fdb4-4fbc-b3b4-64b9d10576bd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedTermOfContract1_2413c777-cd43-4922-b90e-6329a36cc4f9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedTermOfContract1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_e6aa1fac-9ce0-4ed1-b276-5b714318b455" xlink:to="loc_us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedTermOfContract1_2413c777-cd43-4922-b90e-6329a36cc4f9" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/DebtandFinancingArrangementsScheduleofDebtDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#DebtandFinancingArrangementsScheduleofDebtDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/DebtandFinancingArrangementsScheduleofDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_91a98029-249e-4404-9181-1764cdebeb38" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_7ed29861-78e4-4a42-bd4f-83fe360324b1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_91a98029-249e-4404-9181-1764cdebeb38" xlink:to="loc_us-gaap_DebtInstrumentTable_7ed29861-78e4-4a42-bd4f-83fe360324b1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_7ec4b023-97ac-4d0b-a2d0-9deb0eef980b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_7ed29861-78e4-4a42-bd4f-83fe360324b1" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_7ec4b023-97ac-4d0b-a2d0-9deb0eef980b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_7ec4b023-97ac-4d0b-a2d0-9deb0eef980b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_7ec4b023-97ac-4d0b-a2d0-9deb0eef980b" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_7ec4b023-97ac-4d0b-a2d0-9deb0eef980b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_e838d9fc-8fd7-4481-b58a-4fadc1c38c58" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_7ec4b023-97ac-4d0b-a2d0-9deb0eef980b" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_e838d9fc-8fd7-4481-b58a-4fadc1c38c58" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnsecuredDebtMember_96ed5e7a-01f0-451a-99ac-30e446c3cba7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_UnsecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_e838d9fc-8fd7-4481-b58a-4fadc1c38c58" xlink:to="loc_us-gaap_UnsecuredDebtMember_96ed5e7a-01f0-451a-99ac-30e446c3cba7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_3ae7dc94-a43a-455c-8f3d-78750db84274" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_7ed29861-78e4-4a42-bd4f-83fe360324b1" xlink:to="loc_us-gaap_DebtInstrumentAxis_3ae7dc94-a43a-455c-8f3d-78750db84274" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_3ae7dc94-a43a-455c-8f3d-78750db84274_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_3ae7dc94-a43a-455c-8f3d-78750db84274" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_3ae7dc94-a43a-455c-8f3d-78750db84274_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_16e2d981-6f1a-40d2-ac7d-bf650b20f626" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_3ae7dc94-a43a-455c-8f3d-78750db84274" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_16e2d981-6f1a-40d2-ac7d-bf650b20f626" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2026Member_0b8d773e-7256-4bd5-bca5-8503965ac8f9" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_16e2d981-6f1a-40d2-ac7d-bf650b20f626" xlink:to="loc_gxo_UnsecuredNotesDue2026Member_0b8d773e-7256-4bd5-bca5-8503965ac8f9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2029Member_74ac800e-b28a-45ff-964d-6c7711cc64f6" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_16e2d981-6f1a-40d2-ac7d-bf650b20f626" xlink:to="loc_gxo_UnsecuredNotesDue2029Member_74ac800e-b28a-45ff-964d-6c7711cc64f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2031Member_94d990c2-6c9d-4050-8d5f-57e9c71fe288" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2031Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_16e2d981-6f1a-40d2-ac7d-bf650b20f626" xlink:to="loc_gxo_UnsecuredNotesDue2031Member_94d990c2-6c9d-4050-8d5f-57e9c71fe288" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2034Member_c5e79ac6-dd65-4ec5-af6e-423e30d39bb1" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2034Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_16e2d981-6f1a-40d2-ac7d-bf650b20f626" xlink:to="loc_gxo_UnsecuredNotesDue2034Member_c5e79ac6-dd65-4ec5-af6e-423e30d39bb1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_ThreeYearTermLoanMember_32a50298-5ecb-42b0-8ff2-8ab55ae302cc" xlink:href="gxo-20241231.xsd#gxo_ThreeYearTermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_16e2d981-6f1a-40d2-ac7d-bf650b20f626" xlink:to="loc_gxo_ThreeYearTermLoanMember_32a50298-5ecb-42b0-8ff2-8ab55ae302cc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_FiveYearTermLoanMember_00430472-7b22-4015-a0f7-ce312ff2ce60" xlink:href="gxo-20241231.xsd#gxo_FiveYearTermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_16e2d981-6f1a-40d2-ac7d-bf650b20f626" xlink:to="loc_gxo_FiveYearTermLoanMember_00430472-7b22-4015-a0f7-ce312ff2ce60" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_FinanceLeasesAndOtherMember_69eb28f2-8422-4993-8037-84b894560b59" xlink:href="gxo-20241231.xsd#gxo_FinanceLeasesAndOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_16e2d981-6f1a-40d2-ac7d-bf650b20f626" xlink:to="loc_gxo_FinanceLeasesAndOtherMember_69eb28f2-8422-4993-8037-84b894560b59" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_8f9a767a-5433-401a-95e8-a023ce2cc80e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_7ed29861-78e4-4a42-bd4f-83fe360324b1" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_8f9a767a-5433-401a-95e8-a023ce2cc80e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8f9a767a-5433-401a-95e8-a023ce2cc80e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_8f9a767a-5433-401a-95e8-a023ce2cc80e" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8f9a767a-5433-401a-95e8-a023ce2cc80e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_d496fde0-a3a9-4fd4-93ed-9ce8961c34c9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_8f9a767a-5433-401a-95e8-a023ce2cc80e" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_d496fde0-a3a9-4fd4-93ed-9ce8961c34c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_653a41aa-7aff-4837-b0a1-87473f723006" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_d496fde0-a3a9-4fd4-93ed-9ce8961c34c9" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_653a41aa-7aff-4837-b0a1-87473f723006" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_81263d92-de6a-4d00-af05-925859e6a2b4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_7ed29861-78e4-4a42-bd4f-83fe360324b1" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_81263d92-de6a-4d00-af05-925859e6a2b4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_81263d92-de6a-4d00-af05-925859e6a2b4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_81263d92-de6a-4d00-af05-925859e6a2b4" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_81263d92-de6a-4d00-af05-925859e6a2b4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_fe3a0bde-591b-46a0-896b-7ca066bba241" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_81263d92-de6a-4d00-af05-925859e6a2b4" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_fe3a0bde-591b-46a0-896b-7ca066bba241" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_bf310d87-a5fc-41b8-84d6-2a110dd22f29" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_fe3a0bde-591b-46a0-896b-7ca066bba241" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_bf310d87-a5fc-41b8-84d6-2a110dd22f29" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_47d424f8-de7a-42f2-be5c-07d7df8e7fe9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_bf310d87-a5fc-41b8-84d6-2a110dd22f29" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_47d424f8-de7a-42f2-be5c-07d7df8e7fe9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_4582ec39-9eb6-41f3-9e11-88a2fd80fbb8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_91a98029-249e-4404-9181-1764cdebeb38" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_4582ec39-9eb6-41f3-9e11-88a2fd80fbb8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_387ce1c2-3320-4d0e-af6a-982b018b86b1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_91a98029-249e-4404-9181-1764cdebeb38" xlink:to="loc_us-gaap_DebtInstrumentTerm_387ce1c2-3320-4d0e-af6a-982b018b86b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtFairValue_90e6d398-f2f3-4ba4-97c0-13d5cfb62310" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_91a98029-249e-4404-9181-1764cdebeb38" xlink:to="loc_us-gaap_LongTermDebtFairValue_90e6d398-f2f3-4ba4-97c0-13d5cfb62310" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsIncludingCurrentMaturities_b9e29736-f87e-4143-acb9-a1a713ca5c6a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsIncludingCurrentMaturities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_91a98029-249e-4404-9181-1764cdebeb38" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsIncludingCurrentMaturities_b9e29736-f87e-4143-acb9-a1a713ca5c6a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent_9222fdcf-4136-4ff4-aee7-bf4412165c44" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_91a98029-249e-4404-9181-1764cdebeb38" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent_9222fdcf-4136-4ff4-aee7-bf4412165c44" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_2ddcd461-1fcb-4aec-828f-f6d8a4f1fb93" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_91a98029-249e-4404-9181-1764cdebeb38" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligations_2ddcd461-1fcb-4aec-828f-f6d8a4f1fb93" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_64f0dbcd-37e7-4485-902f-21e8ff37aaa1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_91a98029-249e-4404-9181-1764cdebeb38" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_64f0dbcd-37e7-4485-902f-21e8ff37aaa1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_18b037c1-e22e-4d51-b83d-98886954455a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_91a98029-249e-4404-9181-1764cdebeb38" xlink:to="loc_us-gaap_RepaymentsOfDebt_18b037c1-e22e-4d51-b83d-98886954455a" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/DebtandFinancingArrangementsNarrativeDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#DebtandFinancingArrangementsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/DebtandFinancingArrangementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_5fb6ed9b-012d-4252-b807-dd43d8006c25" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_358c08b1-f6ca-4efe-88ec-49103daea1a4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5fb6ed9b-012d-4252-b807-dd43d8006c25" xlink:to="loc_us-gaap_DebtInstrumentTable_358c08b1-f6ca-4efe-88ec-49103daea1a4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_0abff3b2-0613-4f42-998e-6c71dafc3af1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_358c08b1-f6ca-4efe-88ec-49103daea1a4" xlink:to="loc_us-gaap_DebtInstrumentAxis_0abff3b2-0613-4f42-998e-6c71dafc3af1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_0abff3b2-0613-4f42-998e-6c71dafc3af1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_0abff3b2-0613-4f42-998e-6c71dafc3af1" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_0abff3b2-0613-4f42-998e-6c71dafc3af1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_2cb5535f-9f10-4647-93e3-0033bc851b7f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_0abff3b2-0613-4f42-998e-6c71dafc3af1" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_2cb5535f-9f10-4647-93e3-0033bc851b7f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2029And2034Member_3eaf370c-c9cf-4e89-869f-267bc7e4cdb3" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2029And2034Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2cb5535f-9f10-4647-93e3-0033bc851b7f" xlink:to="loc_gxo_UnsecuredNotesDue2029And2034Member_3eaf370c-c9cf-4e89-869f-267bc7e4cdb3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2029Member_b7fa744d-c718-4e77-8e90-5f8fa481a59b" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2cb5535f-9f10-4647-93e3-0033bc851b7f" xlink:to="loc_gxo_UnsecuredNotesDue2029Member_b7fa744d-c718-4e77-8e90-5f8fa481a59b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2034Member_db833472-a2c0-4b32-970a-7bfd084936d6" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2034Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2cb5535f-9f10-4647-93e3-0033bc851b7f" xlink:to="loc_gxo_UnsecuredNotesDue2034Member_db833472-a2c0-4b32-970a-7bfd084936d6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2026Member_5b98eea6-aa1b-4cc8-bb26-5d24269643b0" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2cb5535f-9f10-4647-93e3-0033bc851b7f" xlink:to="loc_gxo_UnsecuredNotesDue2026Member_5b98eea6-aa1b-4cc8-bb26-5d24269643b0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2031Member_ad7a6198-72c6-4caf-9222-a37fddce4c2c" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2031Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2cb5535f-9f10-4647-93e3-0033bc851b7f" xlink:to="loc_gxo_UnsecuredNotesDue2031Member_ad7a6198-72c6-4caf-9222-a37fddce4c2c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_FiveYearTermLoanMember_3704490f-0f7c-4535-917e-2f510cb65103" xlink:href="gxo-20241231.xsd#gxo_FiveYearTermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2cb5535f-9f10-4647-93e3-0033bc851b7f" xlink:to="loc_gxo_FiveYearTermLoanMember_3704490f-0f7c-4535-917e-2f510cb65103" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_ThreeYearTermLoanDue2025Member_bd2936aa-0eda-4394-9af5-22d1cac11e1b" xlink:href="gxo-20241231.xsd#gxo_ThreeYearTermLoanDue2025Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2cb5535f-9f10-4647-93e3-0033bc851b7f" xlink:to="loc_gxo_ThreeYearTermLoanDue2025Member_bd2936aa-0eda-4394-9af5-22d1cac11e1b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_ThreeYearTermLoanDue2027Member_2ba93ffa-3bcf-4ce4-9016-2d48c6ace88f" xlink:href="gxo-20241231.xsd#gxo_ThreeYearTermLoanDue2027Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2cb5535f-9f10-4647-93e3-0033bc851b7f" xlink:to="loc_gxo_ThreeYearTermLoanDue2027Member_2ba93ffa-3bcf-4ce4-9016-2d48c6ace88f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_588afb85-b032-4016-82d9-33454a1eaac9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2cb5535f-9f10-4647-93e3-0033bc851b7f" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_588afb85-b032-4016-82d9-33454a1eaac9" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_981db48a-8099-4765-9b6e-ec70fed20b7a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_358c08b1-f6ca-4efe-88ec-49103daea1a4" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_981db48a-8099-4765-9b6e-ec70fed20b7a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_981db48a-8099-4765-9b6e-ec70fed20b7a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_981db48a-8099-4765-9b6e-ec70fed20b7a" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_981db48a-8099-4765-9b6e-ec70fed20b7a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1605cbdf-8496-424f-95a1-1a6af6ff6acd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_981db48a-8099-4765-9b6e-ec70fed20b7a" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1605cbdf-8496-424f-95a1-1a6af6ff6acd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnsecuredDebtMember_1fad100e-949e-4e9c-a838-3a70128456c5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_UnsecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1605cbdf-8496-424f-95a1-1a6af6ff6acd" xlink:to="loc_us-gaap_UnsecuredDebtMember_1fad100e-949e-4e9c-a838-3a70128456c5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_5116967d-f5cb-4527-92d1-dc1ca9852efb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1605cbdf-8496-424f-95a1-1a6af6ff6acd" xlink:to="loc_us-gaap_LineOfCreditMember_5116967d-f5cb-4527-92d1-dc1ca9852efb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_ae3bbcbf-44dc-4d41-8e8b-ae7f2e0b9d9b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_358c08b1-f6ca-4efe-88ec-49103daea1a4" xlink:to="loc_us-gaap_CreditFacilityAxis_ae3bbcbf-44dc-4d41-8e8b-ae7f2e0b9d9b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_ae3bbcbf-44dc-4d41-8e8b-ae7f2e0b9d9b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_ae3bbcbf-44dc-4d41-8e8b-ae7f2e0b9d9b" xlink:to="loc_us-gaap_CreditFacilityDomain_ae3bbcbf-44dc-4d41-8e8b-ae7f2e0b9d9b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_2b6aaf3d-25b7-45da-8324-31105c5d72f7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_ae3bbcbf-44dc-4d41-8e8b-ae7f2e0b9d9b" xlink:to="loc_us-gaap_CreditFacilityDomain_2b6aaf3d-25b7-45da-8324-31105c5d72f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_BridgeTermLoanCreditAgreementMember_7f566238-8c23-48e0-ab69-aa1fd2486ba0" xlink:href="gxo-20241231.xsd#gxo_BridgeTermLoanCreditAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_2b6aaf3d-25b7-45da-8324-31105c5d72f7" xlink:to="loc_gxo_BridgeTermLoanCreditAgreementMember_7f566238-8c23-48e0-ab69-aa1fd2486ba0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnsecuredDebtMember_dd4334f4-5f3f-495f-9c24-f3d6e183f80b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_UnsecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_2b6aaf3d-25b7-45da-8324-31105c5d72f7" xlink:to="loc_us-gaap_UnsecuredDebtMember_dd4334f4-5f3f-495f-9c24-f3d6e183f80b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_2fa5b794-c0ef-42e6-8f41-f8065b8ef30e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_2b6aaf3d-25b7-45da-8324-31105c5d72f7" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_2fa5b794-c0ef-42e6-8f41-f8065b8ef30e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LetterOfCreditMember_3818036f-6506-423f-b6c9-5f399dadfd12" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LetterOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_2b6aaf3d-25b7-45da-8324-31105c5d72f7" xlink:to="loc_us-gaap_LetterOfCreditMember_3818036f-6506-423f-b6c9-5f399dadfd12" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_f3743f14-3cbf-4bd1-9747-0cfb144889b8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_358c08b1-f6ca-4efe-88ec-49103daea1a4" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_f3743f14-3cbf-4bd1-9747-0cfb144889b8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f3743f14-3cbf-4bd1-9747-0cfb144889b8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_f3743f14-3cbf-4bd1-9747-0cfb144889b8" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f3743f14-3cbf-4bd1-9747-0cfb144889b8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d969cf8d-cc53-435a-ab81-bcea2eece3a3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_f3743f14-3cbf-4bd1-9747-0cfb144889b8" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d969cf8d-cc53-435a-ab81-bcea2eece3a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_WincantonMember_ebea71d9-592d-4341-b074-a2dccba4c6e2" xlink:href="gxo-20241231.xsd#gxo_WincantonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d969cf8d-cc53-435a-ab81-bcea2eece3a3" xlink:to="loc_gxo_WincantonMember_ebea71d9-592d-4341-b074-a2dccba4c6e2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_e11e1076-9d98-4da6-855b-00225750dadc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5fb6ed9b-012d-4252-b807-dd43d8006c25" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_e11e1076-9d98-4da6-855b-00225750dadc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_41966162-da92-4ef7-86d5-38ff281fd769" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5fb6ed9b-012d-4252-b807-dd43d8006c25" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_41966162-da92-4ef7-86d5-38ff281fd769" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_a080fd8a-241e-4da6-939a-f2db586d4834" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5fb6ed9b-012d-4252-b807-dd43d8006c25" xlink:to="loc_us-gaap_DebtInstrumentTerm_a080fd8a-241e-4da6-939a-f2db586d4834" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_f5d2c8c0-29d2-435f-852c-f6c0ae0f7ea3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5fb6ed9b-012d-4252-b807-dd43d8006c25" xlink:to="loc_us-gaap_RepaymentsOfDebt_f5d2c8c0-29d2-435f-852c-f6c0ae0f7ea3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_b8dc1e5b-609b-4e16-b492-ca2fc90c3cef" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5fb6ed9b-012d-4252-b807-dd43d8006c25" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_b8dc1e5b-609b-4e16-b492-ca2fc90c3cef" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage_7b502940-591b-4336-93fb-3cb343f768e5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5fb6ed9b-012d-4252-b807-dd43d8006c25" xlink:to="loc_us-gaap_LineOfCreditFacilityUnusedCapacityCommitmentFeePercentage_7b502940-591b-4336-93fb-3cb343f768e5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_ff122912-34d3-4158-8297-f9eee9f889b9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LineOfCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_5fb6ed9b-012d-4252-b807-dd43d8006c25" xlink:to="loc_us-gaap_LineOfCredit_ff122912-34d3-4158-8297-f9eee9f889b9" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/FairValueMeasurementsandFinancialInstrumentsFairValueofDebtDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#FairValueMeasurementsandFinancialInstrumentsFairValueofDebtDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/FairValueMeasurementsandFinancialInstrumentsFairValueofDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_89706b7a-b63d-451d-bd9d-2d3ff5556436" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_6a52b15e-3204-41c7-9599-57b8692edd92" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_89706b7a-b63d-451d-bd9d-2d3ff5556436" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_6a52b15e-3204-41c7-9599-57b8692edd92" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_84a95bf0-fecc-4c76-9e24-e683fceb7fc7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueByMeasurementBasisAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_6a52b15e-3204-41c7-9599-57b8692edd92" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_84a95bf0-fecc-4c76-9e24-e683fceb7fc7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_84a95bf0-fecc-4c76-9e24-e683fceb7fc7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_84a95bf0-fecc-4c76-9e24-e683fceb7fc7" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_84a95bf0-fecc-4c76-9e24-e683fceb7fc7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2749ded9-2c51-4a3f-8a7d-afaea8958d6d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueDisclosureItemAmountsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_84a95bf0-fecc-4c76-9e24-e683fceb7fc7" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2749ded9-2c51-4a3f-8a7d-afaea8958d6d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_8a291709-d597-47e6-bcc1-1dc3e015b302" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_2749ded9-2c51-4a3f-8a7d-afaea8958d6d" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_8a291709-d597-47e6-bcc1-1dc3e015b302" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_ebd0da43-bd42-492d-b933-d29ff31a7cf2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_8a291709-d597-47e6-bcc1-1dc3e015b302" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_ebd0da43-bd42-492d-b933-d29ff31a7cf2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_ce9cec28-3328-4dc1-87e6-8520ecf3ec29" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_8a291709-d597-47e6-bcc1-1dc3e015b302" xlink:to="loc_us-gaap_CarryingReportedAmountFairValueDisclosureMember_ce9cec28-3328-4dc1-87e6-8520ecf3ec29" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_5b16b1ce-ec21-40b2-8abf-89169b558592" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_6a52b15e-3204-41c7-9599-57b8692edd92" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_5b16b1ce-ec21-40b2-8abf-89169b558592" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_5b16b1ce-ec21-40b2-8abf-89169b558592_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_5b16b1ce-ec21-40b2-8abf-89169b558592" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_5b16b1ce-ec21-40b2-8abf-89169b558592_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_a4620f0b-99a6-4347-8717-61ca9b9ca80d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_5b16b1ce-ec21-40b2-8abf-89169b558592" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_a4620f0b-99a6-4347-8717-61ca9b9ca80d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnsecuredDebtMember_a3bb56ce-f18f-45f2-998f-01e6dca05a27" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_UnsecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_a4620f0b-99a6-4347-8717-61ca9b9ca80d" xlink:to="loc_us-gaap_UnsecuredDebtMember_a3bb56ce-f18f-45f2-998f-01e6dca05a27" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_a6fced52-d26d-4e28-801f-3a5b89e4a0b4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_6a52b15e-3204-41c7-9599-57b8692edd92" xlink:to="loc_us-gaap_DebtInstrumentAxis_a6fced52-d26d-4e28-801f-3a5b89e4a0b4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_a6fced52-d26d-4e28-801f-3a5b89e4a0b4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_a6fced52-d26d-4e28-801f-3a5b89e4a0b4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_a6fced52-d26d-4e28-801f-3a5b89e4a0b4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_2feb2610-b1f9-48ac-9808-707d39479fb8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_a6fced52-d26d-4e28-801f-3a5b89e4a0b4" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_2feb2610-b1f9-48ac-9808-707d39479fb8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2026Member_5934c0b0-010d-46e4-9193-ab77774fd088" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2feb2610-b1f9-48ac-9808-707d39479fb8" xlink:to="loc_gxo_UnsecuredNotesDue2026Member_5934c0b0-010d-46e4-9193-ab77774fd088" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2029Member_bbd3b3c4-ee38-4076-b426-0fc11078b908" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2feb2610-b1f9-48ac-9808-707d39479fb8" xlink:to="loc_gxo_UnsecuredNotesDue2029Member_bbd3b3c4-ee38-4076-b426-0fc11078b908" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2031Member_26a36de1-13a4-47d2-b7f7-426ea15fd814" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2031Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2feb2610-b1f9-48ac-9808-707d39479fb8" xlink:to="loc_gxo_UnsecuredNotesDue2031Member_26a36de1-13a4-47d2-b7f7-426ea15fd814" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UnsecuredNotesDue2034Member_c092a346-ea63-4f04-a6ab-d157a27cc9a7" xlink:href="gxo-20241231.xsd#gxo_UnsecuredNotesDue2034Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2feb2610-b1f9-48ac-9808-707d39479fb8" xlink:to="loc_gxo_UnsecuredNotesDue2034Member_c092a346-ea63-4f04-a6ab-d157a27cc9a7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_ThreeYearTermLoanMember_1beaceed-8bb8-4106-9687-fe4f53329026" xlink:href="gxo-20241231.xsd#gxo_ThreeYearTermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2feb2610-b1f9-48ac-9808-707d39479fb8" xlink:to="loc_gxo_ThreeYearTermLoanMember_1beaceed-8bb8-4106-9687-fe4f53329026" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_FiveYearTermLoanMember_7ec8eb9f-2c6a-44d0-8ebf-1382622c68ff" xlink:href="gxo-20241231.xsd#gxo_FiveYearTermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2feb2610-b1f9-48ac-9808-707d39479fb8" xlink:to="loc_gxo_FiveYearTermLoanMember_7ec8eb9f-2c6a-44d0-8ebf-1382622c68ff" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_7b9453b9-09b9-430d-8761-47230f9a3535" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_6a52b15e-3204-41c7-9599-57b8692edd92" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_7b9453b9-09b9-430d-8761-47230f9a3535" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7b9453b9-09b9-430d-8761-47230f9a3535_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_7b9453b9-09b9-430d-8761-47230f9a3535" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7b9453b9-09b9-430d-8761-47230f9a3535_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7ffb414c-45b4-4c06-b4a9-0d5cbe3c8533" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_7b9453b9-09b9-430d-8761-47230f9a3535" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7ffb414c-45b4-4c06-b4a9-0d5cbe3c8533" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_f67ee8a7-3dc0-4fab-87b8-621063a2d1df" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_7ffb414c-45b4-4c06-b4a9-0d5cbe3c8533" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_f67ee8a7-3dc0-4fab-87b8-621063a2d1df" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtFairValue_5252626e-a27f-4774-a61d-64b50ad6d568" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_89706b7a-b63d-451d-bd9d-2d3ff5556436" xlink:to="loc_us-gaap_LongTermDebtFairValue_5252626e-a27f-4774-a61d-64b50ad6d568" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_a0b946dc-0eb8-4033-bafd-44db1fa11a7e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_89706b7a-b63d-451d-bd9d-2d3ff5556436" xlink:to="loc_us-gaap_DebtInstrumentTerm_a0b946dc-0eb8-4033-bafd-44db1fa11a7e" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/FairValueMeasurementsandFinancialInstrumentsNarrativeDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#FairValueMeasurementsandFinancialInstrumentsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/FairValueMeasurementsandFinancialInstrumentsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_1f092074-a0b1-408a-86ab-7c3eb89af196" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_6aa72431-a96e-447d-aaf5-7921c95652fe" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_1f092074-a0b1-408a-86ab-7c3eb89af196" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_6aa72431-a96e-447d-aaf5-7921c95652fe" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_ab5f4b39-a567-4a41-82be-7c07444831cf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_6aa72431-a96e-447d-aaf5-7921c95652fe" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_ab5f4b39-a567-4a41-82be-7c07444831cf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_ab5f4b39-a567-4a41-82be-7c07444831cf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_ab5f4b39-a567-4a41-82be-7c07444831cf" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_ab5f4b39-a567-4a41-82be-7c07444831cf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_28d75616-8d1f-4272-ad19-c80e51e18e9e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_ab5f4b39-a567-4a41-82be-7c07444831cf" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_28d75616-8d1f-4272-ad19-c80e51e18e9e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_CrossCurrencySwapDue2027And2028Member_a752863e-3bce-4866-a75e-02f2f3f94d60" xlink:href="gxo-20241231.xsd#gxo_CrossCurrencySwapDue2027And2028Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_28d75616-8d1f-4272-ad19-c80e51e18e9e" xlink:to="loc_gxo_CrossCurrencySwapDue2027And2028Member_a752863e-3bce-4866-a75e-02f2f3f94d60" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_CrossCurrencySwapMaturedMember_e865e419-049c-4a1c-b2e2-1ad15d2b7147" xlink:href="gxo-20241231.xsd#gxo_CrossCurrencySwapMaturedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_28d75616-8d1f-4272-ad19-c80e51e18e9e" xlink:to="loc_gxo_CrossCurrencySwapMaturedMember_e865e419-049c-4a1c-b2e2-1ad15d2b7147" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_CrossCurrencySwapDue2025And2029Member_2e9c2a9b-ad40-4437-b659-bea5b4d40446" xlink:href="gxo-20241231.xsd#gxo_CrossCurrencySwapDue2025And2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_28d75616-8d1f-4272-ad19-c80e51e18e9e" xlink:to="loc_gxo_CrossCurrencySwapDue2025And2029Member_2e9c2a9b-ad40-4437-b659-bea5b4d40446" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_47b55f11-c6ab-4671-aa83-75183e875f5f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_28d75616-8d1f-4272-ad19-c80e51e18e9e" xlink:to="loc_us-gaap_InterestRateSwapMember_47b55f11-c6ab-4671-aa83-75183e875f5f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_6508d798-0888-41d4-92f1-d2e2cda919e7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_28d75616-8d1f-4272-ad19-c80e51e18e9e" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_6508d798-0888-41d4-92f1-d2e2cda919e7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_8ed5493c-dfb9-4689-85b3-142eeee7b679" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_6aa72431-a96e-447d-aaf5-7921c95652fe" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_8ed5493c-dfb9-4689-85b3-142eeee7b679" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_8ed5493c-dfb9-4689-85b3-142eeee7b679_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_8ed5493c-dfb9-4689-85b3-142eeee7b679" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_8ed5493c-dfb9-4689-85b3-142eeee7b679_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_f32a8646-2bec-464b-b6ce-b6ff056f7d31" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_8ed5493c-dfb9-4689-85b3-142eeee7b679" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_f32a8646-2bec-464b-b6ce-b6ff056f7d31" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncurrentAssetsMember_371204cb-c6f5-4115-907e-ba8046be71ac" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNoncurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_f32a8646-2bec-464b-b6ce-b6ff056f7d31" xlink:to="loc_us-gaap_OtherNoncurrentAssetsMember_371204cb-c6f5-4115-907e-ba8046be71ac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_79c734cb-3f0f-4614-9636-48812285364a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_6aa72431-a96e-447d-aaf5-7921c95652fe" xlink:to="loc_us-gaap_HedgingDesignationAxis_79c734cb-3f0f-4614-9636-48812285364a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_79c734cb-3f0f-4614-9636-48812285364a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_79c734cb-3f0f-4614-9636-48812285364a" xlink:to="loc_us-gaap_HedgingDesignationDomain_79c734cb-3f0f-4614-9636-48812285364a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_ec7aa056-8c17-4b44-9e05-5f671b032165" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_79c734cb-3f0f-4614-9636-48812285364a" xlink:to="loc_us-gaap_HedgingDesignationDomain_ec7aa056-8c17-4b44-9e05-5f671b032165" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_52138a5d-7600-4a5d-ad15-8981570a54bf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_ec7aa056-8c17-4b44-9e05-5f671b032165" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_52138a5d-7600-4a5d-ad15-8981570a54bf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_f62fee3e-532c-422c-9764-03ee431f9162" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_6aa72431-a96e-447d-aaf5-7921c95652fe" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_f62fee3e-532c-422c-9764-03ee431f9162" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_f62fee3e-532c-422c-9764-03ee431f9162_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_f62fee3e-532c-422c-9764-03ee431f9162" xlink:to="loc_us-gaap_HedgingRelationshipDomain_f62fee3e-532c-422c-9764-03ee431f9162_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_8838ccc4-5081-4847-b466-1d7b7d3ad08f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_f62fee3e-532c-422c-9764-03ee431f9162" xlink:to="loc_us-gaap_HedgingRelationshipDomain_8838ccc4-5081-4847-b466-1d7b7d3ad08f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_b5f7b32c-37b4-4f3f-837b-7875a8f9c391" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_8838ccc4-5081-4847-b466-1d7b7d3ad08f" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_b5f7b32c-37b4-4f3f-837b-7875a8f9c391" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_NumberOfDerivativeInstrumentsAmended_43acdf8f-9177-4797-85f0-5e2e6b0bfbf8" xlink:href="gxo-20241231.xsd#gxo_NumberOfDerivativeInstrumentsAmended"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_1f092074-a0b1-408a-86ab-7c3eb89af196" xlink:to="loc_gxo_NumberOfDerivativeInstrumentsAmended_43acdf8f-9177-4797-85f0-5e2e6b0bfbf8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_f25abe7c-b586-4f30-a8c7-34ba9a2a7cff" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_1f092074-a0b1-408a-86ab-7c3eb89af196" xlink:to="loc_us-gaap_DerivativeNotionalAmount_f25abe7c-b586-4f30-a8c7-34ba9a2a7cff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTermOfContract_28d2fe2d-2bcb-492a-86cd-158075f99361" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_1f092074-a0b1-408a-86ab-7c3eb89af196" xlink:to="loc_us-gaap_DerivativeTermOfContract_28d2fe2d-2bcb-492a-86cd-158075f99361" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/FairValueMeasurementsandFinancialInstrumentsFairValuebyBalanceSheetLocationDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#FairValueMeasurementsandFinancialInstrumentsFairValuebyBalanceSheetLocationDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/FairValueMeasurementsandFinancialInstrumentsFairValuebyBalanceSheetLocationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_ea020bf2-7ccf-44b2-bb06-f331ed2a74f0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_13d9490d-2ce8-4e93-ac2f-a6be6b798c40" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_ea020bf2-7ccf-44b2-bb06-f331ed2a74f0" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_13d9490d-2ce8-4e93-ac2f-a6be6b798c40" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_760936db-b03e-4128-973d-34f88a0548c0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_13d9490d-2ce8-4e93-ac2f-a6be6b798c40" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_760936db-b03e-4128-973d-34f88a0548c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_760936db-b03e-4128-973d-34f88a0548c0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_760936db-b03e-4128-973d-34f88a0548c0" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_760936db-b03e-4128-973d-34f88a0548c0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_ee315792-82d2-41e8-95e9-644ad6dc162a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_760936db-b03e-4128-973d-34f88a0548c0" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_ee315792-82d2-41e8-95e9-644ad6dc162a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentAssetsMember_8e45ba74-8d33-4f86-a95b-049ac202130f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherCurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_ee315792-82d2-41e8-95e9-644ad6dc162a" xlink:to="loc_us-gaap_OtherCurrentAssetsMember_8e45ba74-8d33-4f86-a95b-049ac202130f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncurrentAssetsMember_7014e87b-e326-4d23-be78-7fd8243298bd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNoncurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_ee315792-82d2-41e8-95e9-644ad6dc162a" xlink:to="loc_us-gaap_OtherNoncurrentAssetsMember_7014e87b-e326-4d23-be78-7fd8243298bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentLiabilitiesMember_059f743b-e5b3-49a1-9970-19ad31a43d93" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherCurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_ee315792-82d2-41e8-95e9-644ad6dc162a" xlink:to="loc_us-gaap_OtherCurrentLiabilitiesMember_059f743b-e5b3-49a1-9970-19ad31a43d93" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncurrentLiabilitiesMember_166cfe76-472b-47ce-8318-d0b82d1be328" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherNoncurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_ee315792-82d2-41e8-95e9-644ad6dc162a" xlink:to="loc_us-gaap_OtherNoncurrentLiabilitiesMember_166cfe76-472b-47ce-8318-d0b82d1be328" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_37affa3a-e70a-46ef-b65e-10510982414e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_13d9490d-2ce8-4e93-ac2f-a6be6b798c40" xlink:to="loc_us-gaap_HedgingDesignationAxis_37affa3a-e70a-46ef-b65e-10510982414e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_37affa3a-e70a-46ef-b65e-10510982414e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_37affa3a-e70a-46ef-b65e-10510982414e" xlink:to="loc_us-gaap_HedgingDesignationDomain_37affa3a-e70a-46ef-b65e-10510982414e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_a7377b43-cf44-4ef2-94d7-09c0fc2f12b6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_37affa3a-e70a-46ef-b65e-10510982414e" xlink:to="loc_us-gaap_HedgingDesignationDomain_a7377b43-cf44-4ef2-94d7-09c0fc2f12b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_b7549d28-40e2-4d55-b3d0-da21ebbc7e20" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_a7377b43-cf44-4ef2-94d7-09c0fc2f12b6" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_b7549d28-40e2-4d55-b3d0-da21ebbc7e20" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_ca8f9a3d-8fdc-424e-869e-71d97085fd59" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_a7377b43-cf44-4ef2-94d7-09c0fc2f12b6" xlink:to="loc_us-gaap_NondesignatedMember_ca8f9a3d-8fdc-424e-869e-71d97085fd59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_bf039f15-6669-4c8e-a711-f5584e9dc33e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_13d9490d-2ce8-4e93-ac2f-a6be6b798c40" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_bf039f15-6669-4c8e-a711-f5584e9dc33e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_bf039f15-6669-4c8e-a711-f5584e9dc33e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_bf039f15-6669-4c8e-a711-f5584e9dc33e" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_bf039f15-6669-4c8e-a711-f5584e9dc33e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_9fa77264-a07a-432d-97a2-8ee52e6bcde3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_bf039f15-6669-4c8e-a711-f5584e9dc33e" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_9fa77264-a07a-432d-97a2-8ee52e6bcde3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_18f4098e-d954-440e-b1ae-c350e05b083d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_9fa77264-a07a-432d-97a2-8ee52e6bcde3" xlink:to="loc_us-gaap_InterestRateSwapMember_18f4098e-d954-440e-b1ae-c350e05b083d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_25199d9c-1f83-4027-b7c3-8eb3e4f181c2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_9fa77264-a07a-432d-97a2-8ee52e6bcde3" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_25199d9c-1f83-4027-b7c3-8eb3e4f181c2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeOptionMember_8692f2e1-19c3-4598-926a-96c53945ad8f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignExchangeOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_9fa77264-a07a-432d-97a2-8ee52e6bcde3" xlink:to="loc_us-gaap_ForeignExchangeOptionMember_8692f2e1-19c3-4598-926a-96c53945ad8f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_da76a75e-27be-4f5a-a3a5-d2595bad5473" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_9fa77264-a07a-432d-97a2-8ee52e6bcde3" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_da76a75e-27be-4f5a-a3a5-d2595bad5473" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_21702070-9f99-4dc2-a3f2-f345e864ee6f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_ea020bf2-7ccf-44b2-bb06-f331ed2a74f0" xlink:to="loc_us-gaap_DerivativeNotionalAmount_21702070-9f99-4dc2-a3f2-f345e864ee6f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_6eeb2120-17ce-4d50-8143-d80c7457302e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_ea020bf2-7ccf-44b2-bb06-f331ed2a74f0" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_6eeb2120-17ce-4d50-8143-d80c7457302e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_688822ce-c0fd-4ad2-a4d0-bd2b917fa441" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_ea020bf2-7ccf-44b2-bb06-f331ed2a74f0" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_688822ce-c0fd-4ad2-a4d0-bd2b917fa441" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/FairValueMeasurementsandFinancialInstrumentsDerivativeandNonderivativeInstrumentsDesignatedasHedgesDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#FairValueMeasurementsandFinancialInstrumentsDerivativeandNonderivativeInstrumentsDesignatedasHedgesDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/FairValueMeasurementsandFinancialInstrumentsDerivativeandNonderivativeInstrumentsDesignatedasHedgesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_6c253ce2-f5e0-4956-8c51-9942d8cb2865" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_5240f086-66cf-417f-88dd-281b34307e3e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_6c253ce2-f5e0-4956-8c51-9942d8cb2865" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_5240f086-66cf-417f-88dd-281b34307e3e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_e7d83417-51d7-4d1a-b72d-1749177329d9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_5240f086-66cf-417f-88dd-281b34307e3e" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_e7d83417-51d7-4d1a-b72d-1749177329d9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_e7d83417-51d7-4d1a-b72d-1749177329d9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_e7d83417-51d7-4d1a-b72d-1749177329d9" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_e7d83417-51d7-4d1a-b72d-1749177329d9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_3b8fed17-b909-4926-a048-394ea3b6d44f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_e7d83417-51d7-4d1a-b72d-1749177329d9" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_3b8fed17-b909-4926-a048-394ea3b6d44f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrencySwapMember_f5d9b38b-1ba6-49f5-aee0-1bf8a41ae8dc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CurrencySwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_3b8fed17-b909-4926-a048-394ea3b6d44f" xlink:to="loc_us-gaap_CurrencySwapMember_f5d9b38b-1ba6-49f5-aee0-1bf8a41ae8dc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_d81c471d-0517-4221-8755-a5533b2cca8a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_3b8fed17-b909-4926-a048-394ea3b6d44f" xlink:to="loc_us-gaap_InterestRateSwapMember_d81c471d-0517-4221-8755-a5533b2cca8a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeContractMember_8fd2453d-50cd-4717-b795-44b41cc815ce" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignExchangeContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_3b8fed17-b909-4926-a048-394ea3b6d44f" xlink:to="loc_us-gaap_ForeignExchangeContractMember_8fd2453d-50cd-4717-b795-44b41cc815ce" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_4e5ed3e4-6bf3-4aa7-8325-fb17930b8aa3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_5240f086-66cf-417f-88dd-281b34307e3e" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_4e5ed3e4-6bf3-4aa7-8325-fb17930b8aa3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_4e5ed3e4-6bf3-4aa7-8325-fb17930b8aa3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_4e5ed3e4-6bf3-4aa7-8325-fb17930b8aa3" xlink:to="loc_us-gaap_HedgingRelationshipDomain_4e5ed3e4-6bf3-4aa7-8325-fb17930b8aa3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_6772b942-6d1d-4e63-b10d-9424db699814" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_4e5ed3e4-6bf3-4aa7-8325-fb17930b8aa3" xlink:to="loc_us-gaap_HedgingRelationshipDomain_6772b942-6d1d-4e63-b10d-9424db699814" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetInvestmentHedgingMember_ff19cb57-258a-435d-8200-8c8942ed36eb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NetInvestmentHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_6772b942-6d1d-4e63-b10d-9424db699814" xlink:to="loc_us-gaap_NetInvestmentHedgingMember_ff19cb57-258a-435d-8200-8c8942ed36eb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_b0ef5330-d283-4ad7-b820-00134e7878c0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_6772b942-6d1d-4e63-b10d-9424db699814" xlink:to="loc_us-gaap_CashFlowHedgingMember_b0ef5330-d283-4ad7-b820-00134e7878c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_06f46474-023f-487e-aa9a-7829c10ee91a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_5240f086-66cf-417f-88dd-281b34307e3e" xlink:to="loc_us-gaap_HedgingDesignationAxis_06f46474-023f-487e-aa9a-7829c10ee91a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_06f46474-023f-487e-aa9a-7829c10ee91a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_06f46474-023f-487e-aa9a-7829c10ee91a" xlink:to="loc_us-gaap_HedgingDesignationDomain_06f46474-023f-487e-aa9a-7829c10ee91a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_ff557e4f-9562-45ec-83e8-ffcd685e1a5b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_06f46474-023f-487e-aa9a-7829c10ee91a" xlink:to="loc_us-gaap_HedgingDesignationDomain_ff557e4f-9562-45ec-83e8-ffcd685e1a5b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_0b4893b6-e536-449d-bd27-2e38b0d80882" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_ff557e4f-9562-45ec-83e8-ffcd685e1a5b" xlink:to="loc_us-gaap_NondesignatedMember_0b4893b6-e536-449d-bd27-2e38b0d80882" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_e86aa01e-9015-434f-81ba-d3d8a1846607" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_6c253ce2-f5e0-4956-8c51-9942d8cb2865" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_e86aa01e-9015-434f-81ba-d3d8a1846607" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_fb492e78-85c2-4b7c-9cba-709302459b43" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_6c253ce2-f5e0-4956-8c51-9942d8cb2865" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_fb492e78-85c2-4b7c-9cba-709302459b43" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseBeforeAdjustmentsAndTax_c00f9be0-55fc-4489-b182-50b8c560cb98" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseBeforeAdjustmentsAndTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_6c253ce2-f5e0-4956-8c51-9942d8cb2865" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossDerivativeExcludedComponentIncreaseDecreaseBeforeAdjustmentsAndTax_c00f9be0-55fc-4489-b182-50b8c560cb98" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_dfec2ce0-74d5-4beb-a140-60ae5e68c93b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_6c253ce2-f5e0-4956-8c51-9942d8cb2865" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_dfec2ce0-74d5-4beb-a140-60ae5e68c93b" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/StockholdersEquityDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#StockholdersEquityDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/StockholdersEquityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_9a7c711b-c469-43c4-9134-8929fb564a7e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_265c7e38-de50-4338-9ba9-0365696a012e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_9a7c711b-c469-43c4-9134-8929fb564a7e" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_265c7e38-de50-4338-9ba9-0365696a012e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_45c8f523-1f3d-4ecd-9765-925697c81a6b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_265c7e38-de50-4338-9ba9-0365696a012e" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_45c8f523-1f3d-4ecd-9765-925697c81a6b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_45c8f523-1f3d-4ecd-9765-925697c81a6b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_45c8f523-1f3d-4ecd-9765-925697c81a6b" xlink:to="loc_us-gaap_EquityComponentDomain_45c8f523-1f3d-4ecd-9765-925697c81a6b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_2660694d-a572-485f-a2af-a88718e2436a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_45c8f523-1f3d-4ecd-9765-925697c81a6b" xlink:to="loc_us-gaap_EquityComponentDomain_2660694d-a572-485f-a2af-a88718e2436a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_0f6c011f-afcf-4d75-81ab-5abded6a3ce8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2660694d-a572-485f-a2af-a88718e2436a" xlink:to="loc_us-gaap_AccumulatedForeignCurrencyAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_0f6c011f-afcf-4d75-81ab-5abded6a3ce8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_AccumulatedGainLossNetInvestmentHedgingIncludingNoncontrollingInterestMember_78d382a4-1e2e-45ec-a235-d331ad7ee83d" xlink:href="gxo-20241231.xsd#gxo_AccumulatedGainLossNetInvestmentHedgingIncludingNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2660694d-a572-485f-a2af-a88718e2436a" xlink:to="loc_gxo_AccumulatedGainLossNetInvestmentHedgingIncludingNoncontrollingInterestMember_78d382a4-1e2e-45ec-a235-d331ad7ee83d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_7739f5b9-4631-4bcf-bc76-86e218832a9d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2660694d-a572-485f-a2af-a88718e2436a" xlink:to="loc_us-gaap_AccumulatedGainLossCashFlowHedgeIncludingNoncontrollingInterestMember_7739f5b9-4631-4bcf-bc76-86e218832a9d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_a2eac46f-4525-4a7f-949f-75289030bebb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2660694d-a572-485f-a2af-a88718e2436a" xlink:to="loc_us-gaap_AccumulatedDefinedBenefitPlansAdjustmentIncludingPortionAttributableToNoncontrollingInterestMember_a2eac46f-4525-4a7f-949f-75289030bebb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AociAttributableToNoncontrollingInterestMember_828a470a-db4e-49e7-82b1-be631dcfab38" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AociAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2660694d-a572-485f-a2af-a88718e2436a" xlink:to="loc_us-gaap_AociAttributableToNoncontrollingInterestMember_828a470a-db4e-49e7-82b1-be631dcfab38" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_1765b49f-9838-4320-a42f-70149a0b6631" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2660694d-a572-485f-a2af-a88718e2436a" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_1765b49f-9838-4320-a42f-70149a0b6631" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_6ef1ad61-d432-445a-83bb-2ca18f53cbaf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_9a7c711b-c469-43c4-9134-8929fb564a7e" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_6ef1ad61-d432-445a-83bb-2ca18f53cbaf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0c026794-4705-4d35-8f8f-4103286050d6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_6ef1ad61-d432-445a-83bb-2ca18f53cbaf" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_0c026794-4705-4d35-8f8f-4103286050d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_72c514ae-5669-4cb0-a616-167c241c016a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_6ef1ad61-d432-445a-83bb-2ca18f53cbaf" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossBeforeReclassificationsNetOfTax_72c514ae-5669-4cb0-a616-167c241c016a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_8f86f1e6-6a6d-4625-bf49-4db7cd4ac689" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_6ef1ad61-d432-445a-83bb-2ca18f53cbaf" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax_8f86f1e6-6a6d-4625-bf49-4db7cd4ac689" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_cb337186-82c3-45b2-8007-6fceb38b552d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_6ef1ad61-d432-445a-83bb-2ca18f53cbaf" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_cb337186-82c3-45b2-8007-6fceb38b552d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_906b3acf-d6d0-4d34-a170-4b987d347625" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_6ef1ad61-d432-445a-83bb-2ca18f53cbaf" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_906b3acf-d6d0-4d34-a170-4b987d347625" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_StockholdersEquityTransferFromParent_a4604f11-9cbf-4261-b328-fc1e4acad3ef" xlink:href="gxo-20241231.xsd#gxo_StockholdersEquityTransferFromParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_6ef1ad61-d432-445a-83bb-2ca18f53cbaf" xlink:to="loc_gxo_StockholdersEquityTransferFromParent_a4604f11-9cbf-4261-b328-fc1e4acad3ef" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_65b523ae-296d-4479-9f0c-38a682fd3c05" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/StockBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#StockBasedCompensationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/StockBasedCompensationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f22a4020-2a6c-45a4-a30f-a7ede43f8226" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f22a4020-2a6c-45a4-a30f-a7ede43f8226" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_cd427fc4-2294-4f8c-9e65-35b94ef14ba2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f22a4020-2a6c-45a4-a30f-a7ede43f8226" xlink:to="loc_us-gaap_PlanNameAxis_cd427fc4-2294-4f8c-9e65-35b94ef14ba2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_cd427fc4-2294-4f8c-9e65-35b94ef14ba2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_cd427fc4-2294-4f8c-9e65-35b94ef14ba2" xlink:to="loc_us-gaap_PlanNameDomain_cd427fc4-2294-4f8c-9e65-35b94ef14ba2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_e429eae6-b0d4-4941-8a45-ddab2d9511e5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_cd427fc4-2294-4f8c-9e65-35b94ef14ba2" xlink:to="loc_us-gaap_PlanNameDomain_e429eae6-b0d4-4941-8a45-ddab2d9511e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_A2021OmnibusIncentivePlanMember_76998f5b-4aaf-4e7c-9b8a-9d289b02c9c5" xlink:href="gxo-20241231.xsd#gxo_A2021OmnibusIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_e429eae6-b0d4-4941-8a45-ddab2d9511e5" xlink:to="loc_gxo_A2021OmnibusIncentivePlanMember_76998f5b-4aaf-4e7c-9b8a-9d289b02c9c5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_fea13bf5-d5bc-404a-8030-a09261fd7b40" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f22a4020-2a6c-45a4-a30f-a7ede43f8226" xlink:to="loc_us-gaap_AwardTypeAxis_fea13bf5-d5bc-404a-8030-a09261fd7b40" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_fea13bf5-d5bc-404a-8030-a09261fd7b40_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_fea13bf5-d5bc-404a-8030-a09261fd7b40" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_fea13bf5-d5bc-404a-8030-a09261fd7b40_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c1362589-823e-46a3-bdad-59142e7694ae" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_fea13bf5-d5bc-404a-8030-a09261fd7b40" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c1362589-823e-46a3-bdad-59142e7694ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_a8a6cbab-56a4-4b5e-b0fe-f3b30a78d801" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c1362589-823e-46a3-bdad-59142e7694ae" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_a8a6cbab-56a4-4b5e-b0fe-f3b30a78d801" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_2b5303ed-2895-41be-9d70-3d18d7d1c295" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c1362589-823e-46a3-bdad-59142e7694ae" xlink:to="loc_us-gaap_PerformanceSharesMember_2b5303ed-2895-41be-9d70-3d18d7d1c295" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_d40b8f7d-5422-4f15-8e30-8087901145c3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c1362589-823e-46a3-bdad-59142e7694ae" xlink:to="loc_us-gaap_EmployeeStockOptionMember_d40b8f7d-5422-4f15-8e30-8087901145c3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_RestrictedStockUnitsRSUsAndPerformanceSharesMember_a507348e-c32a-48d5-ab89-34010aee233a" xlink:href="gxo-20241231.xsd#gxo_RestrictedStockUnitsRSUsAndPerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c1362589-823e-46a3-bdad-59142e7694ae" xlink:to="loc_gxo_RestrictedStockUnitsRSUsAndPerformanceSharesMember_a507348e-c32a-48d5-ab89-34010aee233a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_RestrictedStockAwardsMember_423a4cc4-b196-43c4-a452-0575c21dce61" xlink:href="gxo-20241231.xsd#gxo_RestrictedStockAwardsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c1362589-823e-46a3-bdad-59142e7694ae" xlink:to="loc_gxo_RestrictedStockAwardsMember_423a4cc4-b196-43c4-a452-0575c21dce61" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_0ac5378e-f262-44e8-8a99-ea897f00d867" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_0ac5378e-f262-44e8-8a99-ea897f00d867" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_3c516e33-a201-484a-9afd-ae053831eeee" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_3c516e33-a201-484a-9afd-ae053831eeee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_a7990559-79c6-4fcc-8cac-cce3a37952e9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_a7990559-79c6-4fcc-8cac-cce3a37952e9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_26db7154-cae1-458f-bc64-e731bc28021e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_26db7154-cae1-458f-bc64-e731bc28021e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_6f514d1b-3973-484f-8b71-46ad10c8d1a2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_6f514d1b-3973-484f-8b71-46ad10c8d1a2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_c81543ba-e11d-4993-881b-4031a8a18ce6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_c81543ba-e11d-4993-881b-4031a8a18ce6" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_e05c1450-461a-4f79-b62c-39a9da6cbd59" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_e05c1450-461a-4f79-b62c-39a9da6cbd59" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_e4ae4db1-27c2-4c5b-a692-93eef22f1a0d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_e4ae4db1-27c2-4c5b-a692-93eef22f1a0d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_3f7a5c4f-1616-491e-b6de-d7b43378ddb4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_3f7a5c4f-1616-491e-b6de-d7b43378ddb4" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_815a63d6-fe08-4705-a2e4-4e23b3179345" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_815a63d6-fe08-4705-a2e4-4e23b3179345" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_f8fbe08c-d51f-4261-bef7-a66bf504f538" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_f8fbe08c-d51f-4261-bef7-a66bf504f538" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_b649da3a-68d5-450a-88a0-d4e10b546e2e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_b649da3a-68d5-450a-88a0-d4e10b546e2e" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_f4952c95-3d40-4903-8235-b757476c295b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_f4952c95-3d40-4903-8235-b757476c295b" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_6b798829-c810-41dc-90dc-426197959f85" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_6b798829-c810-41dc-90dc-426197959f85" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantedInPeriodFairValue_6c713959-4955-4f88-a3ae-4523707a1dac" xlink:href="gxo-20241231.xsd#gxo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantedInPeriodFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_029c5539-66c2-4c8d-91aa-7cc972a7c255" xlink:to="loc_gxo_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantedInPeriodFairValue_6c713959-4955-4f88-a3ae-4523707a1dac" xlink:type="arc" order="14"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/StockBasedCompensationScheduleofStockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#StockBasedCompensationScheduleofStockBasedCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/StockBasedCompensationScheduleofStockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_623bb1b8-3e1d-43a9-8776-cf477b1e410a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_919d1fd3-4975-4c0b-8485-57f107d23896" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_623bb1b8-3e1d-43a9-8776-cf477b1e410a" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_919d1fd3-4975-4c0b-8485-57f107d23896" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_484c1b05-c3a0-432c-ad41-2a1a3dbc763f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_919d1fd3-4975-4c0b-8485-57f107d23896" xlink:to="loc_us-gaap_AwardTypeAxis_484c1b05-c3a0-432c-ad41-2a1a3dbc763f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_484c1b05-c3a0-432c-ad41-2a1a3dbc763f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_484c1b05-c3a0-432c-ad41-2a1a3dbc763f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_484c1b05-c3a0-432c-ad41-2a1a3dbc763f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_930da83a-6838-45fb-aa54-e2ec29c536b5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_484c1b05-c3a0-432c-ad41-2a1a3dbc763f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_930da83a-6838-45fb-aa54-e2ec29c536b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_451fbae4-ee0a-4873-98e4-df1cfc2a97fc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_930da83a-6838-45fb-aa54-e2ec29c536b5" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_451fbae4-ee0a-4873-98e4-df1cfc2a97fc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_53d1daf5-4571-4d8d-aee6-19529f2073ce" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_930da83a-6838-45fb-aa54-e2ec29c536b5" xlink:to="loc_us-gaap_PerformanceSharesMember_53d1daf5-4571-4d8d-aee6-19529f2073ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_67985882-e826-4bb8-be2d-195bb0e2b1f8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_930da83a-6838-45fb-aa54-e2ec29c536b5" xlink:to="loc_us-gaap_EmployeeStockOptionMember_67985882-e826-4bb8-be2d-195bb0e2b1f8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_RestrictedStockAwardsMember_843b6528-6165-4e76-8afe-1fe4faaeae75" xlink:href="gxo-20241231.xsd#gxo_RestrictedStockAwardsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_930da83a-6838-45fb-aa54-e2ec29c536b5" xlink:to="loc_gxo_RestrictedStockAwardsMember_843b6528-6165-4e76-8afe-1fe4faaeae75" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_6830b914-0031-404d-b3fb-7a84978cd038" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_623bb1b8-3e1d-43a9-8776-cf477b1e410a" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_6830b914-0031-404d-b3fb-7a84978cd038" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_610bbb37-a934-45ee-af4f-cc7e191298c9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_623bb1b8-3e1d-43a9-8776-cf477b1e410a" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_610bbb37-a934-45ee-af4f-cc7e191298c9" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/StockBasedCompensationScheduleofEstimatedFairValueDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#StockBasedCompensationScheduleofEstimatedFairValueDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/StockBasedCompensationScheduleofEstimatedFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d0578593-5c09-41f3-83b7-b4dae7561985" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7d3ff487-1dd7-459a-a00f-37745711a8c7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d0578593-5c09-41f3-83b7-b4dae7561985" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7d3ff487-1dd7-459a-a00f-37745711a8c7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_2fc52e82-408f-43df-abe8-20efea27caee" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7d3ff487-1dd7-459a-a00f-37745711a8c7" xlink:to="loc_us-gaap_AwardTypeAxis_2fc52e82-408f-43df-abe8-20efea27caee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2fc52e82-408f-43df-abe8-20efea27caee_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_2fc52e82-408f-43df-abe8-20efea27caee" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2fc52e82-408f-43df-abe8-20efea27caee_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6c831e13-d356-44e7-ad4f-984387665cde" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_2fc52e82-408f-43df-abe8-20efea27caee" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6c831e13-d356-44e7-ad4f-984387665cde" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_35371f92-72ac-4e84-a682-9efaf72d080e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6c831e13-d356-44e7-ad4f-984387665cde" xlink:to="loc_us-gaap_EmployeeStockOptionMember_35371f92-72ac-4e84-a682-9efaf72d080e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_45a90b94-7ed4-43c0-ae9a-770ffe747578" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6c831e13-d356-44e7-ad4f-984387665cde" xlink:to="loc_us-gaap_PerformanceSharesMember_45a90b94-7ed4-43c0-ae9a-770ffe747578" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_011e90f8-6b1c-4731-8640-25b17919877e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d0578593-5c09-41f3-83b7-b4dae7561985" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_011e90f8-6b1c-4731-8640-25b17919877e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_d897213b-1884-426f-a553-4aa9d2c1fc59" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d0578593-5c09-41f3-83b7-b4dae7561985" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_d897213b-1884-426f-a553-4aa9d2c1fc59" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/StockBasedCompensationScheduleofRSUandPRSUawardactivityDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#StockBasedCompensationScheduleofRSUandPRSUawardactivityDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/StockBasedCompensationScheduleofRSUandPRSUawardactivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2e30e73-a2f6-44c1-a0aa-96e4ce33b275" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8c5381c7-c246-4cb2-b65e-044878cfde0f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2e30e73-a2f6-44c1-a0aa-96e4ce33b275" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8c5381c7-c246-4cb2-b65e-044878cfde0f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_5ff51736-ee14-487a-b5cc-cba51199ebeb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8c5381c7-c246-4cb2-b65e-044878cfde0f" xlink:to="loc_us-gaap_AwardTypeAxis_5ff51736-ee14-487a-b5cc-cba51199ebeb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5ff51736-ee14-487a-b5cc-cba51199ebeb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_5ff51736-ee14-487a-b5cc-cba51199ebeb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5ff51736-ee14-487a-b5cc-cba51199ebeb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e28fc5cb-fc42-43b1-b87e-f5a10ba1a0e1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_5ff51736-ee14-487a-b5cc-cba51199ebeb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e28fc5cb-fc42-43b1-b87e-f5a10ba1a0e1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_2f042e13-3f29-4349-9510-d79cbfc43aa0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e28fc5cb-fc42-43b1-b87e-f5a10ba1a0e1" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_2f042e13-3f29-4349-9510-d79cbfc43aa0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_2e204f28-775f-43d5-9e9a-5fce8e46d110" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e28fc5cb-fc42-43b1-b87e-f5a10ba1a0e1" xlink:to="loc_us-gaap_PerformanceSharesMember_2e204f28-775f-43d5-9e9a-5fce8e46d110" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_b8cb9438-dfbc-499e-907f-f85cc4fe488a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2e30e73-a2f6-44c1-a0aa-96e4ce33b275" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_b8cb9438-dfbc-499e-907f-f85cc4fe488a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_c69ec804-8ebe-48cc-93b2-a876a4e6bbc5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_b8cb9438-dfbc-499e-907f-f85cc4fe488a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_c69ec804-8ebe-48cc-93b2-a876a4e6bbc5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_a997d469-3f42-4293-b7ef-1b10d04139da" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_b8cb9438-dfbc-499e-907f-f85cc4fe488a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_a997d469-3f42-4293-b7ef-1b10d04139da" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_f703e5da-c951-405d-873f-18231c5f2576" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_b8cb9438-dfbc-499e-907f-f85cc4fe488a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_f703e5da-c951-405d-873f-18231c5f2576" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_17b4d759-f2e1-4f08-912c-2a578997c0c1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_b8cb9438-dfbc-499e-907f-f85cc4fe488a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_17b4d759-f2e1-4f08-912c-2a578997c0c1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_85e83fca-302a-4f1c-954b-f5af6245b052" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_1ea9077b-524e-4a2e-9db6-e80e170d5e55" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b2e30e73-a2f6-44c1-a0aa-96e4ce33b275" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_1ea9077b-524e-4a2e-9db6-e80e170d5e55" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_7e0006c7-7ca5-4e11-9e4e-860044dc1d35" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_1ea9077b-524e-4a2e-9db6-e80e170d5e55" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_7e0006c7-7ca5-4e11-9e4e-860044dc1d35" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_240f2927-b21f-4684-8035-b8ef336702d4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_1ea9077b-524e-4a2e-9db6-e80e170d5e55" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_240f2927-b21f-4684-8035-b8ef336702d4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_5db90712-9368-47d8-82e5-4132f89c6f38" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_1ea9077b-524e-4a2e-9db6-e80e170d5e55" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_5db90712-9368-47d8-82e5-4132f89c6f38" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_683c59ef-7d3b-42e0-b3ee-c589db75a7d1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_1ea9077b-524e-4a2e-9db6-e80e170d5e55" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_683c59ef-7d3b-42e0-b3ee-c589db75a7d1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_c94aa940-659c-405b-a262-c625d255be5a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/EmployeeBenefitPlansScheduleofChangeinProjectedBenefitObligationsDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#EmployeeBenefitPlansScheduleofChangeinProjectedBenefitObligationsDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/EmployeeBenefitPlansScheduleofChangeinProjectedBenefitObligationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_cd751865-bca8-4c10-b6bd-32baf7eebeab" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_6b004bdb-fadf-438a-a5cf-dc9a29f1f9a8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_cd751865-bca8-4c10-b6bd-32baf7eebeab" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_6b004bdb-fadf-438a-a5cf-dc9a29f1f9a8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_ecb2e233-702f-465f-a164-2201d3a5b1ae" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_6b004bdb-fadf-438a-a5cf-dc9a29f1f9a8" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_ecb2e233-702f-465f-a164-2201d3a5b1ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_ecb2e233-702f-465f-a164-2201d3a5b1ae_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_ecb2e233-702f-465f-a164-2201d3a5b1ae" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_ecb2e233-702f-465f-a164-2201d3a5b1ae_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_ba94c0d8-6f89-40d2-befb-7e07c1c69dbd" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_ecb2e233-702f-465f-a164-2201d3a5b1ae" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_ba94c0d8-6f89-40d2-befb-7e07c1c69dbd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_998f80e7-eaa2-4e70-a5d0-84174fd1fb65" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_ba94c0d8-6f89-40d2-befb-7e07c1c69dbd" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_998f80e7-eaa2-4e70-a5d0-84174fd1fb65" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_5660235c-85e0-4b42-af9b-53b208b39ec7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_cd751865-bca8-4c10-b6bd-32baf7eebeab" xlink:to="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_5660235c-85e0-4b42-af9b-53b208b39ec7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligation_de596969-903c-4973-88da-1f9265ad4d06" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanBenefitObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_5660235c-85e0-4b42-af9b-53b208b39ec7" xlink:to="loc_us-gaap_DefinedBenefitPlanBenefitObligation_de596969-903c-4973-88da-1f9265ad4d06" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsBenefitObligation_8568b5b7-1c6c-428d-8db8-f85063f97be5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsBenefitObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_5660235c-85e0-4b42-af9b-53b208b39ec7" xlink:to="loc_us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsBenefitObligation_8568b5b7-1c6c-428d-8db8-f85063f97be5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_bd115546-b987-48ca-aa68-21e9f317432c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_5660235c-85e0-4b42-af9b-53b208b39ec7" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_bd115546-b987-48ca-aa68-21e9f317432c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_7648c988-0aa0-4a4c-bc7a-fc92830f8523" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanActuarialGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_5660235c-85e0-4b42-af9b-53b208b39ec7" xlink:to="loc_us-gaap_DefinedBenefitPlanActuarialGainLoss_7648c988-0aa0-4a4c-bc7a-fc92830f8523" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligationPaymentForSettlement_26381d95-7780-4255-81aa-ae3807a810c8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanBenefitObligationPaymentForSettlement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_5660235c-85e0-4b42-af9b-53b208b39ec7" xlink:to="loc_us-gaap_DefinedBenefitPlanBenefitObligationPaymentForSettlement_26381d95-7780-4255-81aa-ae3807a810c8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligationBenefitsPaid_09f5c1c0-323e-401c-8e21-8bc83ff03b56" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanBenefitObligationBenefitsPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_5660235c-85e0-4b42-af9b-53b208b39ec7" xlink:to="loc_us-gaap_DefinedBenefitPlanBenefitObligationBenefitsPaid_09f5c1c0-323e-401c-8e21-8bc83ff03b56" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesBenefitObligation_7dbb9291-98c8-4b7e-8a47-ceb678ce1a5e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesBenefitObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInBenefitObligationRollForward_5660235c-85e0-4b42-af9b-53b208b39ec7" xlink:to="loc_us-gaap_DefinedBenefitPlanForeignCurrencyExchangeRateChangesBenefitObligation_7dbb9291-98c8-4b7e-8a47-ceb678ce1a5e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanBenefitObligation_dc8a79fa-079a-442a-a87c-601d0419c405" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanBenefitObligation"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/EmployeeBenefitPlansScheduleofChangeinFairValueofPlanAssetsandFundedStatusDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#EmployeeBenefitPlansScheduleofChangeinFairValueofPlanAssetsandFundedStatusDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/EmployeeBenefitPlansScheduleofChangeinFairValueofPlanAssetsandFundedStatusDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_6f1d349d-3b46-4630-af96-021f225776dc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_985df0c1-45c5-44f8-b615-7c3eea5a6a58" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_6f1d349d-3b46-4630-af96-021f225776dc" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_985df0c1-45c5-44f8-b615-7c3eea5a6a58" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_f5df6380-89c9-4e15-b5f8-59569f930803" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_985df0c1-45c5-44f8-b615-7c3eea5a6a58" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_f5df6380-89c9-4e15-b5f8-59569f930803" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_f5df6380-89c9-4e15-b5f8-59569f930803_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_f5df6380-89c9-4e15-b5f8-59569f930803" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_f5df6380-89c9-4e15-b5f8-59569f930803_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_e94c40bf-d026-44ea-8f2d-ceead293ab21" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_f5df6380-89c9-4e15-b5f8-59569f930803" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_e94c40bf-d026-44ea-8f2d-ceead293ab21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_43e69073-92f3-4af0-b17b-7a0730200feb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_e94c40bf-d026-44ea-8f2d-ceead293ab21" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_43e69073-92f3-4af0-b17b-7a0730200feb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_3f8c0777-ace7-4ef6-ab2f-5c1067b748af" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_6f1d349d-3b46-4630-af96-021f225776dc" xlink:to="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_3f8c0777-ace7-4ef6-ab2f-5c1067b748af" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_be48e336-a16b-4613-ae78-94d7ff69bdd9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_3f8c0777-ace7-4ef6-ab2f-5c1067b748af" xlink:to="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_be48e336-a16b-4613-ae78-94d7ff69bdd9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets_45ffd535-d169-4d54-82f8-c2871c7fcfb1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_3f8c0777-ace7-4ef6-ab2f-5c1067b748af" xlink:to="loc_us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets_45ffd535-d169-4d54-82f8-c2871c7fcfb1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets_b2df1623-f397-42c5-b3ca-0d5bf45d1136" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_3f8c0777-ace7-4ef6-ab2f-5c1067b748af" xlink:to="loc_us-gaap_DefinedBenefitPlanActualReturnOnPlanAssets_b2df1623-f397-42c5-b3ca-0d5bf45d1136" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanContributionsByEmployer_7d4460a7-6900-400d-94af-4652d9f1e11b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanContributionsByEmployer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_3f8c0777-ace7-4ef6-ab2f-5c1067b748af" xlink:to="loc_us-gaap_DefinedBenefitPlanContributionsByEmployer_7d4460a7-6900-400d-94af-4652d9f1e11b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanSettlementsPlanAssets_4ae94957-c732-40c7-9017-02d1336e5237" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanSettlementsPlanAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_3f8c0777-ace7-4ef6-ab2f-5c1067b748af" xlink:to="loc_us-gaap_DefinedBenefitPlanSettlementsPlanAssets_4ae94957-c732-40c7-9017-02d1336e5237" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanPlanAssetsBenefitsPaid_b2b54cb0-38b5-48fa-8e37-f7b0827d3bea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanPlanAssetsBenefitsPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_3f8c0777-ace7-4ef6-ab2f-5c1067b748af" xlink:to="loc_us-gaap_DefinedBenefitPlanPlanAssetsBenefitsPaid_b2b54cb0-38b5-48fa-8e37-f7b0827d3bea" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanPlanAssetsForeignCurrencyTranslationGainLoss_69227ba2-953c-424a-842a-c28d0d2b8d0a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanPlanAssetsForeignCurrencyTranslationGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_3f8c0777-ace7-4ef6-ab2f-5c1067b748af" xlink:to="loc_us-gaap_DefinedBenefitPlanPlanAssetsForeignCurrencyTranslationGainLoss_69227ba2-953c-424a-842a-c28d0d2b8d0a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_022576bb-c704-4f0d-9a3d-248cc8d0a478" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_82856fb2-b970-45ec-b896-2f58e5c77e18" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanFundedStatusOfPlan"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanChangeInFairValueOfPlanAssetsRollForward_3f8c0777-ace7-4ef6-ab2f-5c1067b748af" xlink:to="loc_us-gaap_DefinedBenefitPlanFundedStatusOfPlan_82856fb2-b970-45ec-b896-2f58e5c77e18" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/EmployeeBenefitPlansScheduleofFundedStatusRecognizedintheConsolidatedBalanceSheetsDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#EmployeeBenefitPlansScheduleofFundedStatusRecognizedintheConsolidatedBalanceSheetsDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/EmployeeBenefitPlansScheduleofFundedStatusRecognizedintheConsolidatedBalanceSheetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_42e1fc1c-2d47-4525-b41e-89726f607637" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_2dc83fb3-0cce-431b-9120-cf441880f70f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_42e1fc1c-2d47-4525-b41e-89726f607637" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_2dc83fb3-0cce-431b-9120-cf441880f70f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_02c0b465-40d6-4d37-8683-749dc8c64dd4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_2dc83fb3-0cce-431b-9120-cf441880f70f" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_02c0b465-40d6-4d37-8683-749dc8c64dd4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_02c0b465-40d6-4d37-8683-749dc8c64dd4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_02c0b465-40d6-4d37-8683-749dc8c64dd4" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_02c0b465-40d6-4d37-8683-749dc8c64dd4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_e5f99f77-ed4d-47ef-840c-94def1c5b8ea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_02c0b465-40d6-4d37-8683-749dc8c64dd4" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_e5f99f77-ed4d-47ef-840c-94def1c5b8ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_b76b7d3a-5fe3-4ab5-b207-06e12179ec22" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_e5f99f77-ed4d-47ef-840c-94def1c5b8ea" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_b76b7d3a-5fe3-4ab5-b207-06e12179ec22" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_fe3e9d35-204a-4026-880f-0f5689d26457" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_42e1fc1c-2d47-4525-b41e-89726f607637" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetGainsLossesBeforeTax_fe3e9d35-204a-4026-880f-0f5689d26457" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_aab5ac7b-ea6f-4e26-9adb-f2464eb10ee0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_42e1fc1c-2d47-4525-b41e-89726f607637" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeNetPriorServiceCostCreditBeforeTax_aab5ac7b-ea6f-4e26-9adb-f2464eb10ee0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_f0e0c74f-45ce-47c0-8645-36af4880a99a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_42e1fc1c-2d47-4525-b41e-89726f607637" xlink:to="loc_us-gaap_DefinedBenefitPlanAccumulatedOtherComprehensiveIncomeBeforeTax_f0e0c74f-45ce-47c0-8645-36af4880a99a" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/EmployeeBenefitPlansScheduleofComponentsofNetPeriodicBenefitCostRecognizedDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#EmployeeBenefitPlansScheduleofComponentsofNetPeriodicBenefitCostRecognizedDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/EmployeeBenefitPlansScheduleofComponentsofNetPeriodicBenefitCostRecognizedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca3fd1c8-44c3-4962-a005-13e559ab7630" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_a608ab27-9fdc-4d5e-aef1-ea6de4eda34d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca3fd1c8-44c3-4962-a005-13e559ab7630" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_a608ab27-9fdc-4d5e-aef1-ea6de4eda34d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_8c918c1a-4767-4c32-93fa-ae4f4eaa6ede" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_a608ab27-9fdc-4d5e-aef1-ea6de4eda34d" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_8c918c1a-4767-4c32-93fa-ae4f4eaa6ede" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_8c918c1a-4767-4c32-93fa-ae4f4eaa6ede_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_8c918c1a-4767-4c32-93fa-ae4f4eaa6ede" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_8c918c1a-4767-4c32-93fa-ae4f4eaa6ede_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_2d4bf084-e35e-451b-a059-67f645a5fe5c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_8c918c1a-4767-4c32-93fa-ae4f4eaa6ede" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_2d4bf084-e35e-451b-a059-67f645a5fe5c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_8bca535a-4f55-427c-aa26-ae88c7e060d8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_2d4bf084-e35e-451b-a059-67f645a5fe5c" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_8bca535a-4f55-427c-aa26-ae88c7e060d8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_95a6bd11-eb57-4240-9bd5-32d7b974236f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ca3fd1c8-44c3-4962-a005-13e559ab7630" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_95a6bd11-eb57-4240-9bd5-32d7b974236f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanInterestCost_4ec0a104-35ba-4097-8a5b-b105370f921c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanInterestCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_95a6bd11-eb57-4240-9bd5-32d7b974236f" xlink:to="loc_us-gaap_DefinedBenefitPlanInterestCost_4ec0a104-35ba-4097-8a5b-b105370f921c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_438d0041-ada5-44ad-858f-8d6e33249ea4" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_95a6bd11-eb57-4240-9bd5-32d7b974236f" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedReturnOnPlanAssets_438d0041-ada5-44ad-858f-8d6e33249ea4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_ed0b2bbb-e7c5-49b2-a578-6a238eb92e99" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_95a6bd11-eb57-4240-9bd5-32d7b974236f" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfPriorServiceCostCredit_ed0b2bbb-e7c5-49b2-a578-6a238eb92e99" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_f1229190-a10e-4181-b34e-02b4a3b21caa" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_95a6bd11-eb57-4240-9bd5-32d7b974236f" xlink:to="loc_us-gaap_DefinedBenefitPlanAmortizationOfGainsLosses_f1229190-a10e-4181-b34e-02b4a3b21caa" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_5fad6bd6-6e5b-43fa-9994-c8fb29ddb0d8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCostAbstract_95a6bd11-eb57-4240-9bd5-32d7b974236f" xlink:to="loc_us-gaap_DefinedBenefitPlanNetPeriodicBenefitCost_5fad6bd6-6e5b-43fa-9994-c8fb29ddb0d8" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/EmployeeBenefitPlansScheduleofAmountsRecognizedinOtherComprehensiveIncomeDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#EmployeeBenefitPlansScheduleofAmountsRecognizedinOtherComprehensiveIncomeDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/EmployeeBenefitPlansScheduleofAmountsRecognizedinOtherComprehensiveIncomeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_2dcc176e-9163-4dca-a445-d3c0e6c50a56" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_fb802d4d-607d-476c-ba71-0b85efe31447" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_2dcc176e-9163-4dca-a445-d3c0e6c50a56" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_fb802d4d-607d-476c-ba71-0b85efe31447" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_45fed386-b2f4-49e0-bd08-6b1e031adace" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_fb802d4d-607d-476c-ba71-0b85efe31447" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_45fed386-b2f4-49e0-bd08-6b1e031adace" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_45fed386-b2f4-49e0-bd08-6b1e031adace_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_45fed386-b2f4-49e0-bd08-6b1e031adace" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_45fed386-b2f4-49e0-bd08-6b1e031adace_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_edd4e46b-b5e3-4250-8064-da7fc702f236" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_45fed386-b2f4-49e0-bd08-6b1e031adace" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_edd4e46b-b5e3-4250-8064-da7fc702f236" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_9d6a769c-436b-47ac-bdbf-912c5d682d4c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_edd4e46b-b5e3-4250-8064-da7fc702f236" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_9d6a769c-436b-47ac-bdbf-912c5d682d4c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_23e633c3-ff6b-45e9-b0df-ea9340948d8d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_2dcc176e-9163-4dca-a445-d3c0e6c50a56" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_23e633c3-ff6b-45e9-b0df-ea9340948d8d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_96e1595c-4ec4-4f20-b64a-c6a75cb712ec" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_23e633c3-ff6b-45e9-b0df-ea9340948d8d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansNetUnamortizedGainLossArisingDuringPeriodBeforeTax_96e1595c-4ec4-4f20-b64a-c6a75cb712ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_7bef4f71-0d39-4734-844a-1782eacd16ac" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_23e633c3-ff6b-45e9-b0df-ea9340948d8d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAmortizationAdjustmentFromAOCIPensionAndOtherPostretirementBenefitPlansForNetPriorServiceCostCreditBeforeTax_7bef4f71-0d39-4734-844a-1782eacd16ac" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_7cbaed2a-2714-47d1-ae3f-29b8c435d732" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeReclassificationAdjustmentsAndTaxAbstract_23e633c3-ff6b-45e9-b0df-ea9340948d8d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossPensionAndOtherPostretirementBenefitPlansAdjustmentBeforeTax_7cbaed2a-2714-47d1-ae3f-29b8c435d732" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/EmployeeBenefitPlansScheduleofWeightedaverageAssumptionsUsedDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#EmployeeBenefitPlansScheduleofWeightedaverageAssumptionsUsedDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/EmployeeBenefitPlansScheduleofWeightedaverageAssumptionsUsedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ad887563-4220-4152-9e67-c213cd78a5c9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_c9058cfc-dd96-48b3-8bd8-f5f0528aff27" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ad887563-4220-4152-9e67-c213cd78a5c9" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_c9058cfc-dd96-48b3-8bd8-f5f0528aff27" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_4a41bf54-2934-45a5-81be-d26639e7fee2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_c9058cfc-dd96-48b3-8bd8-f5f0528aff27" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_4a41bf54-2934-45a5-81be-d26639e7fee2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_4a41bf54-2934-45a5-81be-d26639e7fee2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_4a41bf54-2934-45a5-81be-d26639e7fee2" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_4a41bf54-2934-45a5-81be-d26639e7fee2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_620abd69-804a-44ed-bf35-253ce9bb139f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_4a41bf54-2934-45a5-81be-d26639e7fee2" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_620abd69-804a-44ed-bf35-253ce9bb139f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_f6f8e545-7a9d-4b87-afb2-f9b382c1e7a7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_620abd69-804a-44ed-bf35-253ce9bb139f" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_f6f8e545-7a9d-4b87-afb2-f9b382c1e7a7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanWeightedAverageAssumptionsUsedInCalculatingBenefitObligationAbstract_3b00236a-ac30-45fa-ae26-df845167acfe" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanWeightedAverageAssumptionsUsedInCalculatingBenefitObligationAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ad887563-4220-4152-9e67-c213cd78a5c9" xlink:to="loc_us-gaap_DefinedBenefitPlanWeightedAverageAssumptionsUsedInCalculatingBenefitObligationAbstract_3b00236a-ac30-45fa-ae26-df845167acfe" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate_6e6a9cee-d785-4e89-854b-4227b14546ea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanWeightedAverageAssumptionsUsedInCalculatingBenefitObligationAbstract_3b00236a-ac30-45fa-ae26-df845167acfe" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationDiscountRate_6e6a9cee-d785-4e89-854b-4227b14546ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationRateOfCompensationIncrease_0d4143eb-6e87-4c59-b831-a60a71876906" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationRateOfCompensationIncrease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanWeightedAverageAssumptionsUsedInCalculatingBenefitObligationAbstract_3b00236a-ac30-45fa-ae26-df845167acfe" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingBenefitObligationRateOfCompensationIncrease_0d4143eb-6e87-4c59-b831-a60a71876906" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanWeightedAverageAssumptionsUsedInCalculatingNetPeriodicBenefitCostAbstract_e0308b94-938e-4ded-bfe3-a6fc7b41fc33" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanWeightedAverageAssumptionsUsedInCalculatingNetPeriodicBenefitCostAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_ad887563-4220-4152-9e67-c213cd78a5c9" xlink:to="loc_us-gaap_DefinedBenefitPlanWeightedAverageAssumptionsUsedInCalculatingNetPeriodicBenefitCostAbstract_e0308b94-938e-4ded-bfe3-a6fc7b41fc33" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate_5a1278fa-2757-490b-b2b3-706f560607b6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanWeightedAverageAssumptionsUsedInCalculatingNetPeriodicBenefitCostAbstract_e0308b94-938e-4ded-bfe3-a6fc7b41fc33" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostDiscountRate_5a1278fa-2757-490b-b2b3-706f560607b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease_6af8e8c4-cf1d-4387-95cd-6972cd689b68" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanWeightedAverageAssumptionsUsedInCalculatingNetPeriodicBenefitCostAbstract_e0308b94-938e-4ded-bfe3-a6fc7b41fc33" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostRateOfCompensationIncrease_6af8e8c4-cf1d-4387-95cd-6972cd689b68" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets_dc238563-698c-4542-a351-ac5d96337f79" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanWeightedAverageAssumptionsUsedInCalculatingNetPeriodicBenefitCostAbstract_e0308b94-938e-4ded-bfe3-a6fc7b41fc33" xlink:to="loc_us-gaap_DefinedBenefitPlanAssumptionsUsedCalculatingNetPeriodicBenefitCostExpectedLongTermReturnOnAssets_dc238563-698c-4542-a351-ac5d96337f79" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/EmployeeBenefitPlansNarrativeDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#EmployeeBenefitPlansNarrativeDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/EmployeeBenefitPlansNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_7a072529-978a-4615-8efd-a429823f2791" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_1953d415-b567-4495-90d1-2d8f3fe090e0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_7a072529-978a-4615-8efd-a429823f2791" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_1953d415-b567-4495-90d1-2d8f3fe090e0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_61258f31-156e-4281-821f-5066ede30c2b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_1953d415-b567-4495-90d1-2d8f3fe090e0" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_61258f31-156e-4281-821f-5066ede30c2b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_61258f31-156e-4281-821f-5066ede30c2b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_61258f31-156e-4281-821f-5066ede30c2b" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_61258f31-156e-4281-821f-5066ede30c2b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6869f1bd-61c2-41ad-a3b6-2e44800acc1f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_61258f31-156e-4281-821f-5066ede30c2b" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6869f1bd-61c2-41ad-a3b6-2e44800acc1f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_WincantonMember_615c1a92-8e35-48dc-9472-8021606dfdc5" xlink:href="gxo-20241231.xsd#gxo_WincantonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6869f1bd-61c2-41ad-a3b6-2e44800acc1f" xlink:to="loc_gxo_WincantonMember_615c1a92-8e35-48dc-9472-8021606dfdc5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_00b69564-f75f-42cc-9660-92b0fe5b78e0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_1953d415-b567-4495-90d1-2d8f3fe090e0" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_00b69564-f75f-42cc-9660-92b0fe5b78e0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_00b69564-f75f-42cc-9660-92b0fe5b78e0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_00b69564-f75f-42cc-9660-92b0fe5b78e0" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_00b69564-f75f-42cc-9660-92b0fe5b78e0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_2e7d6e4b-eb00-48a7-a4c1-135b99e21283" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_00b69564-f75f-42cc-9660-92b0fe5b78e0" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_2e7d6e4b-eb00-48a7-a4c1-135b99e21283" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_7e9b3370-90b0-4eb1-8f94-2b0252675eb0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_2e7d6e4b-eb00-48a7-a4c1-135b99e21283" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_7e9b3370-90b0-4eb1-8f94-2b0252675eb0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_bef0004f-c28f-424d-80fc-decc65aa123d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_1953d415-b567-4495-90d1-2d8f3fe090e0" xlink:to="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_bef0004f-c28f-424d-80fc-decc65aa123d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanAssetCategoriesDomain_bef0004f-c28f-424d-80fc-decc65aa123d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PlanAssetCategoriesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_bef0004f-c28f-424d-80fc-decc65aa123d" xlink:to="loc_us-gaap_PlanAssetCategoriesDomain_bef0004f-c28f-424d-80fc-decc65aa123d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanAssetCategoriesDomain_07e6f4e0-bf84-4f61-bec5-5b526bf6ced1" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PlanAssetCategoriesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_bef0004f-c28f-424d-80fc-decc65aa123d" xlink:to="loc_us-gaap_PlanAssetCategoriesDomain_07e6f4e0-bf84-4f61-bec5-5b526bf6ced1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_DefinedBenefitPlanGiltsAndCashMember_b5d29c84-35ea-4d6f-838f-9f7645e99164" xlink:href="gxo-20241231.xsd#gxo_DefinedBenefitPlanGiltsAndCashMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_07e6f4e0-bf84-4f61-bec5-5b526bf6ced1" xlink:to="loc_gxo_DefinedBenefitPlanGiltsAndCashMember_b5d29c84-35ea-4d6f-838f-9f7645e99164" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_DefinedBenefitPlanGrowthAndIncomeAssetsMember_34b97d9d-cf18-4df2-8208-fc4075270238" xlink:href="gxo-20241231.xsd#gxo_DefinedBenefitPlanGrowthAndIncomeAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_07e6f4e0-bf84-4f61-bec5-5b526bf6ced1" xlink:to="loc_gxo_DefinedBenefitPlanGrowthAndIncomeAssetsMember_34b97d9d-cf18-4df2-8208-fc4075270238" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanNameAxis_345dd921-15e7-45af-a0d7-d3acd837dd3e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_1953d415-b567-4495-90d1-2d8f3fe090e0" xlink:to="loc_us-gaap_RetirementPlanNameAxis_345dd921-15e7-45af-a0d7-d3acd837dd3e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanNameDomain_345dd921-15e7-45af-a0d7-d3acd837dd3e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanNameAxis_345dd921-15e7-45af-a0d7-d3acd837dd3e" xlink:to="loc_us-gaap_RetirementPlanNameDomain_345dd921-15e7-45af-a0d7-d3acd837dd3e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanNameDomain_d7715bcc-add7-49aa-b255-c0de3eec3b16" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanNameAxis_345dd921-15e7-45af-a0d7-d3acd837dd3e" xlink:to="loc_us-gaap_RetirementPlanNameDomain_d7715bcc-add7-49aa-b255-c0de3eec3b16" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_UKRetirementPlanMember_4300daca-8f2c-479c-ae2c-22eb641c8548" xlink:href="gxo-20241231.xsd#gxo_UKRetirementPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanNameDomain_d7715bcc-add7-49aa-b255-c0de3eec3b16" xlink:to="loc_gxo_UKRetirementPlanMember_4300daca-8f2c-479c-ae2c-22eb641c8548" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanSponsorLocationAxis_aa677a65-295d-47e6-93c7-ffbd48581426" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanSponsorLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_1953d415-b567-4495-90d1-2d8f3fe090e0" xlink:to="loc_us-gaap_RetirementPlanSponsorLocationAxis_aa677a65-295d-47e6-93c7-ffbd48581426" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanSponsorLocationDomain_aa677a65-295d-47e6-93c7-ffbd48581426_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanSponsorLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanSponsorLocationAxis_aa677a65-295d-47e6-93c7-ffbd48581426" xlink:to="loc_us-gaap_RetirementPlanSponsorLocationDomain_aa677a65-295d-47e6-93c7-ffbd48581426_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanSponsorLocationDomain_6255e52d-11e9-4012-be60-df8052b8dc59" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanSponsorLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanSponsorLocationAxis_aa677a65-295d-47e6-93c7-ffbd48581426" xlink:to="loc_us-gaap_RetirementPlanSponsorLocationDomain_6255e52d-11e9-4012-be60-df8052b8dc59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignPlanMember_c7f2a900-ee1d-4b7c-ac19-0bb9adc52557" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanSponsorLocationDomain_6255e52d-11e9-4012-be60-df8052b8dc59" xlink:to="loc_us-gaap_ForeignPlanMember_c7f2a900-ee1d-4b7c-ac19-0bb9adc52557" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_GB_b0da2e7b-b348-4888-a1fa-38da9021af10" xlink:href="https://xbrl.sec.gov/country/2024/country-2024.xsd#country_GB"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ForeignPlanMember_c7f2a900-ee1d-4b7c-ac19-0bb9adc52557" xlink:to="loc_country_GB_b0da2e7b-b348-4888-a1fa-38da9021af10" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets_c6109bf6-f3ca-4fb2-a47d-231a5fab0e8c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_7a072529-978a-4615-8efd-a429823f2791" xlink:to="loc_us-gaap_DefinedBenefitPlanBusinessCombinationsAndAcquisitionsPlanAssets_c6109bf6-f3ca-4fb2-a47d-231a5fab0e8c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanPlanAssetsTargetAllocationPercentage_2b32423b-7b4e-4516-9670-c161e30f7320" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanPlanAssetsTargetAllocationPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_7a072529-978a-4615-8efd-a429823f2791" xlink:to="loc_us-gaap_DefinedBenefitPlanPlanAssetsTargetAllocationPercentage_2b32423b-7b4e-4516-9670-c161e30f7320" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsNextFiscalYear_78ceb8b2-a4f8-41be-8b54-a7b1649c52b5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsNextFiscalYear"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_7a072529-978a-4615-8efd-a429823f2791" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureEmployerContributionsNextFiscalYear_78ceb8b2-a4f8-41be-8b54-a7b1649c52b5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedContributionPlanCostRecognized_7379613b-144d-470d-871a-5207f788fd0c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedContributionPlanCostRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_7a072529-978a-4615-8efd-a429823f2791" xlink:to="loc_us-gaap_DefinedContributionPlanCostRecognized_7379613b-144d-470d-871a-5207f788fd0c" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/EmployeeBenefitPlansScheduleofFairValuesofInvestmentsHeldinthePensionPlansbyMajorAssetCategoryDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#EmployeeBenefitPlansScheduleofFairValuesofInvestmentsHeldinthePensionPlansbyMajorAssetCategoryDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/EmployeeBenefitPlansScheduleofFairValuesofInvestmentsHeldinthePensionPlansbyMajorAssetCategoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_aea79830-8b7e-4547-ac5f-ff83a18fc76e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_4c310111-695c-4ab3-8feb-54cbfa5a37dc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_aea79830-8b7e-4547-ac5f-ff83a18fc76e" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_4c310111-695c-4ab3-8feb-54cbfa5a37dc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_f9613b96-a7dc-4119-a71a-8324e32346cf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_4c310111-695c-4ab3-8feb-54cbfa5a37dc" xlink:to="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_f9613b96-a7dc-4119-a71a-8324e32346cf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanAssetCategoriesDomain_f9613b96-a7dc-4119-a71a-8324e32346cf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PlanAssetCategoriesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_f9613b96-a7dc-4119-a71a-8324e32346cf" xlink:to="loc_us-gaap_PlanAssetCategoriesDomain_f9613b96-a7dc-4119-a71a-8324e32346cf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanAssetCategoriesDomain_f9dd750a-e09f-49a2-a996-0f9d2bb8ffce" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PlanAssetCategoriesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DefinedBenefitPlanByPlanAssetCategoriesAxis_f9613b96-a7dc-4119-a71a-8324e32346cf" xlink:to="loc_us-gaap_PlanAssetCategoriesDomain_f9dd750a-e09f-49a2-a996-0f9d2bb8ffce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanCashAndCashEquivalentsMember_b00825ab-9880-4057-ae21-bfef7fdb9951" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_f9dd750a-e09f-49a2-a996-0f9d2bb8ffce" xlink:to="loc_us-gaap_DefinedBenefitPlanCashAndCashEquivalentsMember_b00825ab-9880-4057-ae21-bfef7fdb9951" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FixedIncomeSecuritiesMember_e1a67006-490f-46ed-8378-d8bf0218fc53" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FixedIncomeSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_f9dd750a-e09f-49a2-a996-0f9d2bb8ffce" xlink:to="loc_us-gaap_FixedIncomeSecuritiesMember_e1a67006-490f-46ed-8378-d8bf0218fc53" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_3ddc28b1-3f02-4a1d-b615-0f70aa0bfcaf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_f9dd750a-e09f-49a2-a996-0f9d2bb8ffce" xlink:to="loc_us-gaap_MoneyMarketFundsMember_3ddc28b1-3f02-4a1d-b615-0f70aa0bfcaf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanEquitySecuritiesMember_a6192b4f-24a0-4616-989b-bcf9cc44ca79" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanEquitySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_f9dd750a-e09f-49a2-a996-0f9d2bb8ffce" xlink:to="loc_us-gaap_DefinedBenefitPlanEquitySecuritiesMember_a6192b4f-24a0-4616-989b-bcf9cc44ca79" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepurchaseAgreementsMember_ffc63edb-0681-4d7a-bd47-1c7824ece9fe" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RepurchaseAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_f9dd750a-e09f-49a2-a996-0f9d2bb8ffce" xlink:to="loc_us-gaap_RepurchaseAgreementsMember_ffc63edb-0681-4d7a-bd47-1c7824ece9fe" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivateEquityFundsMember_c2f50745-a685-4207-a0de-a003445b5e66" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PrivateEquityFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanAssetCategoriesDomain_f9dd750a-e09f-49a2-a996-0f9d2bb8ffce" xlink:to="loc_us-gaap_PrivateEquityFundsMember_c2f50745-a685-4207-a0de-a003445b5e66" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ff3f4276-d493-413a-ac4d-793975378240" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_4c310111-695c-4ab3-8feb-54cbfa5a37dc" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ff3f4276-d493-413a-ac4d-793975378240" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ff3f4276-d493-413a-ac4d-793975378240_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ff3f4276-d493-413a-ac4d-793975378240" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ff3f4276-d493-413a-ac4d-793975378240_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ac6192a0-485b-4bf3-82bf-f16f01a44be7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ff3f4276-d493-413a-ac4d-793975378240" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ac6192a0-485b-4bf3-82bf-f16f01a44be7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel12And3Member_20773b20-212e-46e1-9e0c-bf54f9e80599" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel12And3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ac6192a0-485b-4bf3-82bf-f16f01a44be7" xlink:to="loc_us-gaap_FairValueInputsLevel12And3Member_20773b20-212e-46e1-9e0c-bf54f9e80599" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_9592d675-8c47-4539-8e44-a82be4b6b320" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueInputsLevel12And3Member_20773b20-212e-46e1-9e0c-bf54f9e80599" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_9592d675-8c47-4539-8e44-a82be4b6b320" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_b34e6fa4-2e3d-4591-a630-a75627f9593e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueInputsLevel12And3Member_20773b20-212e-46e1-9e0c-bf54f9e80599" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_b34e6fa4-2e3d-4591-a630-a75627f9593e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasuredAtNetAssetValuePerShareMember_08380828-cfa7-42b9-8fe4-72713b38edc3" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_FairValueMeasuredAtNetAssetValuePerShareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ac6192a0-485b-4bf3-82bf-f16f01a44be7" xlink:to="loc_us-gaap_FairValueMeasuredAtNetAssetValuePerShareMember_08380828-cfa7-42b9-8fe4-72713b38edc3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_ac95acb0-03ff-4c55-a241-eda24a29a5ac" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_4c310111-695c-4ab3-8feb-54cbfa5a37dc" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_ac95acb0-03ff-4c55-a241-eda24a29a5ac" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_ac95acb0-03ff-4c55-a241-eda24a29a5ac_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_ac95acb0-03ff-4c55-a241-eda24a29a5ac" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_ac95acb0-03ff-4c55-a241-eda24a29a5ac_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_e3f8d44c-35dd-4eef-996c-3e484372e8ff" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_ac95acb0-03ff-4c55-a241-eda24a29a5ac" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_e3f8d44c-35dd-4eef-996c-3e484372e8ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_cea4f74d-d39b-4f46-9347-d38f9bd8ec8e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_e3f8d44c-35dd-4eef-996c-3e484372e8ff" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_cea4f74d-d39b-4f46-9347-d38f9bd8ec8e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanAssetsTargetAllocationsAbstract_b1d30679-3a59-400a-925e-2be47a49ce6f" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanAssetsTargetAllocationsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_aea79830-8b7e-4547-ac5f-ff83a18fc76e" xlink:to="loc_us-gaap_DefinedBenefitPlanAssetsTargetAllocationsAbstract_b1d30679-3a59-400a-925e-2be47a49ce6f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_b4000a8d-098a-43c9-9ec7-d5de3c575b08" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanFairValueOfPlanAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanAssetsTargetAllocationsAbstract_b1d30679-3a59-400a-925e-2be47a49ce6f" xlink:to="loc_us-gaap_DefinedBenefitPlanFairValueOfPlanAssets_b4000a8d-098a-43c9-9ec7-d5de3c575b08" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/EmployeeBenefitPlansScheduleofExpectedBenefitPaymentsDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#EmployeeBenefitPlansScheduleofExpectedBenefitPaymentsDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/EmployeeBenefitPlansScheduleofExpectedBenefitPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_830760c8-0686-4e51-8552-dfa61b5bc8cb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_4659ebc1-3105-4f0b-a5cd-4d60d43ae5f5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_830760c8-0686-4e51-8552-dfa61b5bc8cb" xlink:to="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_4659ebc1-3105-4f0b-a5cd-4d60d43ae5f5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeAxis_3a2ab175-2aa3-4db9-af05-5cae35d3148b" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfDefinedBenefitPlansDisclosuresTable_4659ebc1-3105-4f0b-a5cd-4d60d43ae5f5" xlink:to="loc_us-gaap_RetirementPlanTypeAxis_3a2ab175-2aa3-4db9-af05-5cae35d3148b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_3a2ab175-2aa3-4db9-af05-5cae35d3148b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_3a2ab175-2aa3-4db9-af05-5cae35d3148b" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_3a2ab175-2aa3-4db9-af05-5cae35d3148b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetirementPlanTypeDomain_9094bf9c-3b61-446f-b0cd-47f1bbc9c566" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RetirementPlanTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RetirementPlanTypeAxis_3a2ab175-2aa3-4db9-af05-5cae35d3148b" xlink:to="loc_us-gaap_RetirementPlanTypeDomain_9094bf9c-3b61-446f-b0cd-47f1bbc9c566" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PensionPlansDefinedBenefitMember_8d7cdff2-41f4-4795-af24-9ec3fe08895c" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PensionPlansDefinedBenefitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RetirementPlanTypeDomain_9094bf9c-3b61-446f-b0cd-47f1bbc9c566" xlink:to="loc_us-gaap_PensionPlansDefinedBenefitMember_8d7cdff2-41f4-4795-af24-9ec3fe08895c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_dfc2da2b-fe71-4ff3-a758-ecc8c53f7aac" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_830760c8-0686-4e51-8552-dfa61b5bc8cb" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsNextTwelveMonths_dfc2da2b-fe71-4ff3-a758-ecc8c53f7aac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_931bfb13-a334-4ace-a840-448299977565" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_830760c8-0686-4e51-8552-dfa61b5bc8cb" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearTwo_931bfb13-a334-4ace-a840-448299977565" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_21d36938-f40f-4a30-be10-6db3bea691f0" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_830760c8-0686-4e51-8552-dfa61b5bc8cb" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearThree_21d36938-f40f-4a30-be10-6db3bea691f0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_705bf89c-3557-4875-8db6-c981b1538621" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_830760c8-0686-4e51-8552-dfa61b5bc8cb" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFour_705bf89c-3557-4875-8db6-c981b1538621" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_a5d5fb09-db41-4f11-b9d1-7b88dc330358" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_830760c8-0686-4e51-8552-dfa61b5bc8cb" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsYearFive_a5d5fb09-db41-4f11-b9d1-7b88dc330358" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_954d0944-f2cd-478a-a87a-12c2816502f2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DefinedBenefitPlanDisclosureLineItems_830760c8-0686-4e51-8552-dfa61b5bc8cb" xlink:to="loc_us-gaap_DefinedBenefitPlanExpectedFutureBenefitPaymentsFiveFiscalYearsThereafter_954d0944-f2cd-478a-a87a-12c2816502f2" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/RestructuringChargesandOtherScheduleofRestructuringandRelatedCostsDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#RestructuringChargesandOtherScheduleofRestructuringandRelatedCostsDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/RestructuringChargesandOtherScheduleofRestructuringandRelatedCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_286026e3-0a02-4eb3-9e4f-e188ef27f31a" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_0cbef869-38f9-41ab-aa0e-eb902741274e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_286026e3-0a02-4eb3-9e4f-e188ef27f31a" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_0cbef869-38f9-41ab-aa0e-eb902741274e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_d78ea03c-b26a-49c2-bb46-ecdc4d388f7d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_0cbef869-38f9-41ab-aa0e-eb902741274e" xlink:to="loc_us-gaap_RestructuringPlanAxis_d78ea03c-b26a-49c2-bb46-ecdc4d388f7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_d78ea03c-b26a-49c2-bb46-ecdc4d388f7d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_d78ea03c-b26a-49c2-bb46-ecdc4d388f7d" xlink:to="loc_us-gaap_RestructuringPlanDomain_d78ea03c-b26a-49c2-bb46-ecdc4d388f7d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_6dec1175-8c34-47f8-82ec-308cd08e4adb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_d78ea03c-b26a-49c2-bb46-ecdc4d388f7d" xlink:to="loc_us-gaap_RestructuringPlanDomain_6dec1175-8c34-47f8-82ec-308cd08e4adb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_RestructuringActionsMember_dd7ecb9f-4ecb-4a61-bed0-60e2468e7c98" xlink:href="gxo-20241231.xsd#gxo_RestructuringActionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_6dec1175-8c34-47f8-82ec-308cd08e4adb" xlink:to="loc_gxo_RestructuringActionsMember_dd7ecb9f-4ecb-4a61-bed0-60e2468e7c98" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveRollForward_e1274596-9257-4e2e-9cd9-3ccf9979f515" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestructuringReserveRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_286026e3-0a02-4eb3-9e4f-e188ef27f31a" xlink:to="loc_us-gaap_RestructuringReserveRollForward_e1274596-9257-4e2e-9cd9-3ccf9979f515" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_d5d10ad6-afb3-41df-88ae-d3342db71c46" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestructuringReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_e1274596-9257-4e2e-9cd9-3ccf9979f515" xlink:to="loc_us-gaap_RestructuringReserve_d5d10ad6-afb3-41df-88ae-d3342db71c46" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_8a9c7aee-57d2-466a-aaef-26bc6bca2fb5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_e1274596-9257-4e2e-9cd9-3ccf9979f515" xlink:to="loc_us-gaap_RestructuringCharges_8a9c7aee-57d2-466a-aaef-26bc6bca2fb5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRestructuring_37129de6-e41e-45cb-908c-677aa441b748" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PaymentsForRestructuring"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringReserveRollForward_e1274596-9257-4e2e-9cd9-3ccf9979f515" xlink:to="loc_us-gaap_PaymentsForRestructuring_37129de6-e41e-45cb-908c-677aa441b748" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_3b4185d7-32c1-49e3-910c-f54c24fd83d6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestructuringReserve"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/IncomeTaxesOperatingLossandTaxCreditCarryforwardsDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#IncomeTaxesOperatingLossandTaxCreditCarryforwardsDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/IncomeTaxesOperatingLossandTaxCreditCarryforwardsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_6c928e88-f006-41d6-b118-6779b748ccee" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLossCarryforwardsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_a87a61ff-88a6-43ec-82a5-8ea8301a3786" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLossCarryforwardsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_6c928e88-f006-41d6-b118-6779b748ccee" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_a87a61ff-88a6-43ec-82a5-8ea8301a3786" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_06fefaa0-2ea4-47bf-b448-8402188f53a7" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_a87a61ff-88a6-43ec-82a5-8ea8301a3786" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_06fefaa0-2ea4-47bf-b448-8402188f53a7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_06fefaa0-2ea4-47bf-b448-8402188f53a7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_06fefaa0-2ea4-47bf-b448-8402188f53a7" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_06fefaa0-2ea4-47bf-b448-8402188f53a7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_81930da6-2b59-4864-88eb-d3c3cd537953" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_06fefaa0-2ea4-47bf-b448-8402188f53a7" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_81930da6-2b59-4864-88eb-d3c3cd537953" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticCountryMember_33072577-1aa8-44ca-831a-90f83a2445bf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DomesticCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_81930da6-2b59-4864-88eb-d3c3cd537953" xlink:to="loc_us-gaap_DomesticCountryMember_33072577-1aa8-44ca-831a-90f83a2445bf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_1b5323d9-6993-45a5-9553-ad76c181c2a6" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_StateAndLocalJurisdictionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_81930da6-2b59-4864-88eb-d3c3cd537953" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_1b5323d9-6993-45a5-9553-ad76c181c2a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCountryMember_b5879e31-bea1-422c-9f35-687d8495b841" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ForeignCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_81930da6-2b59-4864-88eb-d3c3cd537953" xlink:to="loc_us-gaap_ForeignCountryMember_b5879e31-bea1-422c-9f35-687d8495b841" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_458c9f7e-0932-409a-9d83-2f7040037e0d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_6c928e88-f006-41d6-b118-6779b748ccee" xlink:to="loc_us-gaap_OperatingLossCarryforwards_458c9f7e-0932-409a-9d83-2f7040037e0d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_7fe7819b-365a-4887-95eb-d5a19abd1d16" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_6c928e88-f006-41d6-b118-6779b748ccee" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwardsStateAndLocal_7fe7819b-365a-4887-95eb-d5a19abd1d16" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_d597bdc3-14ee-4c11-9e26-7c139ec4e3bf" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_TaxCreditCarryforwardAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_6c928e88-f006-41d6-b118-6779b748ccee" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_d597bdc3-14ee-4c11-9e26-7c139ec4e3bf" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/IncomeTaxesValuationAllowancesDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#IncomeTaxesValuationAllowancesDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/IncomeTaxesValuationAllowancesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_63f7ee74-5bba-43ac-abc9-207abf44a194" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ValuationAndQualifyingAccountsDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_fd6ee714-b245-4f96-8c52-4c239678c8ae" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_ValuationAndQualifyingAccountsDisclosureTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_63f7ee74-5bba-43ac-abc9-207abf44a194" xlink:to="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_fd6ee714-b245-4f96-8c52-4c239678c8ae" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_bc9e944a-a2b1-4dc4-be9d-8591d3b13fb8" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_fd6ee714-b245-4f96-8c52-4c239678c8ae" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_bc9e944a-a2b1-4dc4-be9d-8591d3b13fb8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_bc9e944a-a2b1-4dc4-be9d-8591d3b13fb8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_bc9e944a-a2b1-4dc4-be9d-8591d3b13fb8" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_bc9e944a-a2b1-4dc4-be9d-8591d3b13fb8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_53200e21-19ce-472a-9075-c257e4a2f07e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_bc9e944a-a2b1-4dc4-be9d-8591d3b13fb8" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_53200e21-19ce-472a-9075-c257e4a2f07e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember_06231467-71c3-481c-8297-9fd1bd1e42e9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_53200e21-19ce-472a-9075-c257e4a2f07e" xlink:to="loc_us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember_06231467-71c3-481c-8297-9fd1bd1e42e9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_792a9c2e-c341-4d67-a323-789f4fb6c7eb" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_fd6ee714-b245-4f96-8c52-4c239678c8ae" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_792a9c2e-c341-4d67-a323-789f4fb6c7eb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_792a9c2e-c341-4d67-a323-789f4fb6c7eb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_792a9c2e-c341-4d67-a323-789f4fb6c7eb" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_792a9c2e-c341-4d67-a323-789f4fb6c7eb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_8deb4ea1-3cb9-4081-a693-e01904dde2da" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_792a9c2e-c341-4d67-a323-789f4fb6c7eb" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_8deb4ea1-3cb9-4081-a693-e01904dde2da" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_PFSwebIncMember_3b5782c8-706e-4d06-9134-15a665d863b2" xlink:href="gxo-20241231.xsd#gxo_PFSwebIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_8deb4ea1-3cb9-4081-a693-e01904dde2da" xlink:to="loc_gxo_PFSwebIncMember_3b5782c8-706e-4d06-9134-15a665d863b2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_d44cbf15-12c2-453a-bb14-8e6741f7a4ff" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_63f7ee74-5bba-43ac-abc9-207abf44a194" xlink:to="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_d44cbf15-12c2-453a-bb14-8e6741f7a4ff" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_27ad2a51-40df-4040-8997-bd536676cc48" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_d44cbf15-12c2-453a-bb14-8e6741f7a4ff" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_27ad2a51-40df-4040-8997-bd536676cc48" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_ec159344-6e95-4950-a090-745ef9270aea" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_d44cbf15-12c2-453a-bb14-8e6741f7a4ff" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_ec159344-6e95-4950-a090-745ef9270aea" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDeductions_bca7946a-1eee-46e3-9d33-fa06ff17eedc" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ValuationAllowancesAndReservesDeductions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_d44cbf15-12c2-453a-bb14-8e6741f7a4ff" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDeductions_bca7946a-1eee-46e3-9d33-fa06ff17eedc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_f310cd3a-71a1-4175-9d45-cc906b842a17" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/CommitmentandContingenciesDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#CommitmentandContingenciesDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/CommitmentandContingenciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_bb9f2eab-6cd4-4dbb-84df-c2c82346833d" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_01324557-8c4c-4109-8979-369604b436b9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_bb9f2eab-6cd4-4dbb-84df-c2c82346833d" xlink:to="loc_us-gaap_LossContingenciesTable_01324557-8c4c-4109-8979-369604b436b9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_feaae8e5-5a23-4c40-9ad5-77004bc25db9" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LossContingenciesByNatureOfContingencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_01324557-8c4c-4109-8979-369604b436b9" xlink:to="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_feaae8e5-5a23-4c40-9ad5-77004bc25db9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_feaae8e5-5a23-4c40-9ad5-77004bc25db9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_feaae8e5-5a23-4c40-9ad5-77004bc25db9" xlink:to="loc_us-gaap_LossContingencyNatureDomain_feaae8e5-5a23-4c40-9ad5-77004bc25db9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNatureDomain_e2d01e67-3ac7-4219-8a5d-fa386193a362" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LossContingencyNatureDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LossContingenciesByNatureOfContingencyAxis_feaae8e5-5a23-4c40-9ad5-77004bc25db9" xlink:to="loc_us-gaap_LossContingencyNatureDomain_e2d01e67-3ac7-4219-8a5d-fa386193a362" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_A2024DepositMember_0db4aaef-644a-4d3a-b1f6-b5922701c696" xlink:href="gxo-20241231.xsd#gxo_A2024DepositMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_e2d01e67-3ac7-4219-8a5d-fa386193a362" xlink:to="loc_gxo_A2024DepositMember_0db4aaef-644a-4d3a-b1f6-b5922701c696" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_January2025DepositMember_5eccae75-9a21-4bef-9d63-ad369c8e171d" xlink:href="gxo-20241231.xsd#gxo_January2025DepositMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingencyNatureDomain_e2d01e67-3ac7-4219-8a5d-fa386193a362" xlink:to="loc_gxo_January2025DepositMember_5eccae75-9a21-4bef-9d63-ad369c8e171d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_9125ad54-9f28-47fd-a28f-a206799e494e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_01324557-8c4c-4109-8979-369604b436b9" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_9125ad54-9f28-47fd-a28f-a206799e494e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_9125ad54-9f28-47fd-a28f-a206799e494e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_9125ad54-9f28-47fd-a28f-a206799e494e" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_9125ad54-9f28-47fd-a28f-a206799e494e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_34a96e91-2f16-411c-944f-c0d29b140096" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_9125ad54-9f28-47fd-a28f-a206799e494e" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_34a96e91-2f16-411c-944f-c0d29b140096" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_4fdd6257-c70b-4c64-ab9d-e51601933a74" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_34a96e91-2f16-411c-944f-c0d29b140096" xlink:to="loc_us-gaap_SubsequentEventMember_4fdd6257-c70b-4c64-ab9d-e51601933a74" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyDamagesAwardedValue_f69e6f46-ee1d-4d30-95c7-c123abb157a5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LossContingencyDamagesAwardedValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_bb9f2eab-6cd4-4dbb-84df-c2c82346833d" xlink:to="loc_us-gaap_LossContingencyDamagesAwardedValue_f69e6f46-ee1d-4d30-95c7-c123abb157a5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalFees_30ba434e-6dea-4429-a25c-56e7705c95e2" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LegalFees"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_bb9f2eab-6cd4-4dbb-84df-c2c82346833d" xlink:to="loc_us-gaap_LegalFees_30ba434e-6dea-4429-a25c-56e7705c95e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_gxo_LossContingencyRangeOfPossibleLossAllegedAmount_29782ce5-1c4b-4d51-b144-20ff56fd518c" xlink:href="gxo-20241231.xsd#gxo_LossContingencyRangeOfPossibleLossAllegedAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_bb9f2eab-6cd4-4dbb-84df-c2c82346833d" xlink:to="loc_gxo_LossContingencyRangeOfPossibleLossAllegedAmount_29782ce5-1c4b-4d51-b144-20ff56fd518c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_c15d3366-de27-4095-9c48-f70f6e39eb62" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_bb9f2eab-6cd4-4dbb-84df-c2c82346833d" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_c15d3366-de27-4095-9c48-f70f6e39eb62" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://gxo.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="gxo-20241231.xsd#SubsequentEventsDetails"/>
  <link:definitionLink xlink:role="http://gxo.com/role/SubsequentEventsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_833ac304-e954-411a-8724-1d20ca762817" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_807f5461-d239-4b73-b9d5-5d1db36ee177" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_833ac304-e954-411a-8724-1d20ca762817" xlink:to="loc_us-gaap_SubsequentEventTable_807f5461-d239-4b73-b9d5-5d1db36ee177" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_1b03ff3c-a2e9-4b90-8186-19c3f8dc45f5" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_807f5461-d239-4b73-b9d5-5d1db36ee177" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_1b03ff3c-a2e9-4b90-8186-19c3f8dc45f5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_1b03ff3c-a2e9-4b90-8186-19c3f8dc45f5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_1b03ff3c-a2e9-4b90-8186-19c3f8dc45f5" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_1b03ff3c-a2e9-4b90-8186-19c3f8dc45f5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_3745b197-f549-4d35-81c9-e1743f221c6e" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_1b03ff3c-a2e9-4b90-8186-19c3f8dc45f5" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_3745b197-f549-4d35-81c9-e1743f221c6e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_4dff0997-1a96-49fc-afa7-b0c913a4d063" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_3745b197-f549-4d35-81c9-e1743f221c6e" xlink:to="loc_us-gaap_SubsequentEventMember_4dff0997-1a96-49fc-afa7-b0c913a4d063" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StockRepurchaseProgramAuthorizedAmount1_7d33e5b1-65da-494a-95d8-b4348c1abc5e" xlink:href="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd#srt_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_833ac304-e954-411a-8724-1d20ca762817" xlink:to="loc_srt_StockRepurchaseProgramAuthorizedAmount1_7d33e5b1-65da-494a-95d8-b4348c1abc5e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-roles-2024.xsd#eedm"/>
  <link:definitionLink xlink:role="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_AssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization" xlink:type="arc" order="101"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd#us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract" xlink:to="loc_us-gaap_LongTermDebtAndCapitalLeaseObligationsCurrent" xlink:type="arc" order="41"/>
  </link:definitionLink>
</link:linkbase>
